Results 81 to 90 of about 4,566,280 (295)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Mechanochemistry for Organic and Inorganic Synthesis

ACS Organic & Inorganic Au
In recent years, mechanochemistry has become an innovative and sustainable alternative to traditional solvent-based synthesis. Mechanochemistry rapidly expanded across a wide range of chemistry fields, including diverse organic compounds and active pharmaceutical ingredients, coordination compounds, organometallic complexes, main group frameworks, and ...
Javier F. Reynes, Felix Leon, Felipe García   +2 more
openaire   +6 more sources

Entry to 2-aminoprolines via electrochemical decarboxylative amidation of N‑acetylamino malonic acid monoesters

Beilstein Journal of Organic Chemistry
The electrochemical synthesis of 2-aminoprolines based on anodic decarboxylation–intramolecular amidation of readily available N-acetylamino malonic acid monoesters is reported. The decarboxylative amidation under Hofer–Moest reaction conditions proceeds
Olesja Koleda, Janis Sadauskis, Darja Antonenko, Edvards Janis Treijs, Raivis Davis Steberis, Edgars Suna   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Critical Point of Conventionally Bred Soft Wheat Varieties in Organic Farming Systems [PDF]

, 2009
Nowdays, wheat is the most important crop for organic farming system. However, the varieties breeded and tested in the conditions of organic farming system are still missing.
Moudry, Jan, Stehno, Zdenek, Konvalina, Petr   +2 more
core   +1 more source

Stability and Phase Transitions of Nontoxic γ-Cyclodextrin-K⁺ Metal-Organic Framework in Various Solvents

Crystals, 2020
Cyclodextrin (CD) has been used to prepare biocompatible and nontoxic metal-organic frameworks (MOFs) suitable for biomedical applications as drug carriers.
Kristīne Krūkle-Bērziņa, Sergey Belyakov, Anatoly Mishnev, Kirill Shubin   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Research Program for Organic Food and Farming in Finland [PDF]

, 2005
The Finnish Ministry of Agriculture and Forestry started a three-year Research Programme on Organic Food and Farming in 2003. The programme consists of 15 projects on different themes covering the whole food chain and has an annual budget of about 2.2 ...
Nykaenen, Arja, Nykänen, Arja
core  

Crystal structure of a two-dimensional metal–organic framework assembled from lithium(I) and γ-cyclodextrin

Acta Crystallographica Section E: Crystallographic Communications, 2020
The crystal structure of the polymeric title compound, catena-poly[[[diaqualithium]-μ-γ-cyclodextrin(1−)-[aqualithium]-μ-γ-cyclodextrin(1−)] pentadecahydrate], {[Li2(C48H79O40)2(H2O)3]·15H2O}n, consists of deprotonated γ-cyclodextrin (CD) molecules ...
Kristine Krukle-Berzina, Sergey Belyakov, Anatoly Mishnev, Kirill Shubin   +3 more
doaj   +1 more source