Results 51 to 60 of about 883,587 (309)

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures

Neurobiology of Disease, 2021
There is a growing body of evidence demonstrating the significant involvement of the sigma-1 chaperone protein in the modulation of seizures. Several sigma-1 receptor (Sig1R) ligands have been demonstrated to regulate the seizure threshold in acute and ...
Edijs Vavers, Baiba Zvejniece, Gundega Stelfa, Baiba Svalbe, Karlis Vilks, Einars Kupats, Rudolfs Mezapuke, Lasma Lauberte, Maija Dambrova, Liga Zvejniece   +9 more
doaj  

Decreases in Circulating Concentrations of Long-Chain Acylcarnitines and Free Fatty Acids During the Glucose Tolerance Test Represent Tissue-Specific Insulin Sensitivity

Frontiers in Endocrinology, 2019
Background: Insulin plays a pivotal role in the regulation of both carbohydrate and lipid intermediate turnover and metabolism. In the transition from a fasted to fed state, insulin action inhibits lipolysis in adipocytes, and acylcarnitine synthesis in ...
Elina Makarova, Elina Makarova, Marina Makrecka-Kuka, Marina Makrecka-Kuka, Karlis Vilks, Karlis Vilks, Kristine Volska, Kristine Volska, Eduards Sevostjanovs, Solveiga Grinberga, Olga Zarkova-Malkova, Maija Dambrova, Maija Dambrova, Edgars Liepinsh   +13 more
doaj   +1 more source

Styrylpyridinium Derivatives for Fluorescent Cell Imaging

Pharmaceuticals, 2023
A set of styrylpyridinium (SP) compounds was synthesised in order to study their spectroscopic and cell labelling properties. The compounds comprised different electron donating parts (julolidine, p-dimethylaminophenyl, p-methoxyphenyl, 3,4,5 ...
Reinis Putralis, Ksenija Korotkaja, Martins Kaukulis, Zhanna Rudevica, Juris Jansons, Olga Nilova, Martins Rucins, Laura Krasnova, Ilona Domracheva, Mara Plotniece, Karlis Pajuste, Arkadij Sobolev, Felikss Rumnieks, Laura Bekere, Anna Zajakina, Aiva Plotniece, Gunars Duburs   +16 more
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Photoinduced 1,2,3,4-tetrahydropyridine ring conversions

Beilstein Journal of Organic Chemistry, 2015
Stable heterocyclic hydroperoxide can be easily prepared as a product of fast oxidation of a 1,2,3,4-tetrahydropyridine by 3O2 if the solution is exposed to sunlight.
Baiba Turovska, Henning Lund, Viesturs Lūsis, Anna Lielpētere, Edvards Liepiņš, Sergejs Beljakovs, Inguna Goba, Jānis Stradiņš   +7 more
doaj   +1 more source

Two mutually complementary synthetic approaches towards 3-substituted 3,4-disubstituted and 1-(2-pyridyl)-substituted isoquinolines

Chimica Techno Acta, 2018
Two mutually complementary synthetic approaches towards 3- and 3,4-disubstituted 1-(2-pyridyl) isoquinolines were studied. The aryne-based method was successfully used for the obtaining of the corresponding the 3-cyano-1-(2-pyridyl)isoquinolines in one ...
I. L. Nikonov, D. S. Kopchuk, A. F. Khasanov, A. P. Krinochkin, E. S. Starnovskaya, Ya. K. Shtaiz, M. I. Savchuk, O. S. Tanya, G. V. Zyryanov, V. L. Rusinov, O. N. Chupakhin   +10 more
doaj   +1 more source

Approaches to the Total Synthesis of Conduramines: A Review

SynOpen, 2022
This review reports on the total synthesis of conduramines, which are formally derived from conduritols, mainly containing a trihydroxy aminocyclohexene core.
Hanumantharayappa Bharathkumar, Jattuboyina Siva Krishna, Banothu Surender, Venkateswara Rao Batchu   +3 more
doaj   +1 more source

Straightforward Synthesis of α,β-Unsaturated Thioesters via Ruthenium-Catalyzed Olefin Cross-Metathesis with Thioacrylate [PDF]

, 2008
The cross-metathesis reaction of S-ethyl thioacrylate with a variety of olefins is effectively catalyzed by using a ruthenium benzylidene olefin metathesis catalyst.
Feringa, Ben L.,, Minnaard, Adriaan J.,, Zijl, Anthoni W. van,   +2 more
core   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source