Results 81 to 90 of about 396,912 (271)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Organisation Man - Women and Organisational Culture [PDF]

Sociological Research Online, 1997
Four decades ago, Whyte (1956), described how a new human expression had become universally evident. This was the notion of the ‘Organisation Man’, an early corporate culture characterised by the middle ranks of managers in large organisations, who were subject to a ‘social ethic’. Under the original conception gender was not an issue.
openaire   +1 more source

SPECIFIC FEATURES OF THE ORGANISATIONAL CULTURE OF THE LOCAL GOVERNMENT [PDF]

The system of local government is presently undergoing a deep reforming process which aims at objectives of paramount importance, the achievement of which depends, more than ever, on substantial changes brought to the values and behaviour patterns ...
Camelia STEFANESCU, Stelian PÂNZARU
core  

Culture and culture change in a higher education context: what works and what doesn’t? [PDF]

, 2012
PUBLISHED VERSION: Organisational culture and culture change are related concepts which have their origins in organisational studies, but also have relevance to higher education and the constitution of contemporary universities. This paper first explores
Baughan, P.
core  

Exploring employee engagement with (corporate) social responsibility: A Social Exchange perspective on organisational participation [PDF]

, 2015
Corporate social responsibility (CSR) is a recognised and common part of business activity. Some of the regularly cited motives behind CSR are employee morale, recruitment and retention, with employees acknowledged as a key organisational stakeholder ...
Corlett, Sandra, Morris, Rachael, Slack, Richard   +2 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

ORGANISATIONAL CULTURE AS AN EFFECTIVE TOOL FOR MANAGING A TELECOMMUNICATIONS ENTERPRISE

Baltic Journal of Economic Studies
The purpose of the article is to study and clarify the substantive characteristics of organisational culture, to substantiate its relationship with the organisational design of enterprise. To determine the key factors of mutual influence on the formation
Natalia Yevtushenko, Olena Gudz, Anzhela Tiazhina   +2 more
doaj   +1 more source

Transformation as part of evolving organisational culture in the South African higher education institutions

Cogent Social Sciences, 2019
The practice of organisational culture plays a major role in enhancing organisational and sustainable growth through innovative leadership and a sound sense of community.
Shadrack Themba Mzangwa
doaj   +1 more source