Results 101 to 110 of about 7,547 (200)

Cytochrome c prompts the recruitment of its nuclear partners SET/TAF-Iβ and NPM1 into biomolecular condensates

iScience
Summary: Compartmentalization of proteins by liquid-liquid phase separation (LLPS) is used by cells to control biochemical reactions spatially and temporally.
Miguel Á. Casado-Combreras, Adrián Velázquez-Campoy, Marlène Martinho, Valérie Belle, Miguel A. De la Rosa, Irene Díaz-Moreno   +5 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Modeling hepatic steatosis with human adult stem cell-derived liver organoids

iScience
Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) remains the most common chronic liver disease worldwide, and appropriate in vitro models are of great significance for investigating pathogenesis and drug screening of MASLD.
Liuyang Zhu, Sen Liu, Ze Wang, Yueyue Yang, Pinsheng Han, Wen Tong, Tianyu Zhao, Libo Wang, Tao Cui, Long Yang, Yamin Zhang   +10 more
doaj   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Revealing the Auxetic Behavior of Biomimetic Multimaterial and Region‐Specific Nanofibrous Fascicle‐Inspired Scaffolds via Synchrotron Multiscale Digital Volume Correlation: Innovative Building Blocks for the Enthesis Regeneration

Advanced Functional Materials, EarlyView.
Enthesis injuries are a worldwide healthcare problem. Biomimetic electrospun enthesis fascicle‐inspired scaffolds, with and without nano‐mineralization are developed. Human Mesenchymal Stromal cells (hMSCs) express the most balanced enthesis markers on the non‐mineralized scaffolds.
Alberto Sensini, Francesca Giacomini, Olga Stamati, Bratislav Lukic, Julie Villanova, Henry Proudhon, Maryse Gille, Zeinab Tahmasebi Birgani, Roman Truckenmüller, Gianluca Tozzi, Martijn van Griensven, Lorenzo Moroni   +11 more
wiley   +1 more source

Cat‐Vibrissa‐Inspired Biomass Fiber Aerogels for Flexible and Highly Sensitive Sensors in Monitoring Human Sport

Advanced Functional Materials, EarlyView.
Inspired by cat vibrissae, biomimetic biomass PHFs/SA aerogels (BFAs) are developed via precursor‐assisted in situ polymerization and freeze‐synergistic assembly. These ultralight, porous pressure sensors exhibit high sensitivity and excellent durability, enabling pulse detection, handwriting recognition, Morse code transmission, and notably real‐time ...
Dandan Xie, Ziwei Chen, Daoxiong Qian, Jian Shi, Wei Zhang, Hideaki Morikawa, Chunhong Zhu   +6 more
wiley   +1 more source

Anisotropic Shear Properties of Organic Interfaces in Bio‐composite Materials

Advanced Functional Materials, EarlyView.
A novel cantilever design enables direct probing of shear properties at single organic interfaces within biocomposite prismatic ultrastructures. By decoupling lateral and torsional shear responses, the method reveals isotropic behavior in Atrina vexillum and pronounced anisotropy in Unio pictorum.
Kian Tadayon, Benny Bar‐On, Igor Zlotnikov   +2 more
wiley   +1 more source

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity

Advanced Functional Materials, EarlyView.
A synthetic DNA‐crosslinked cell culture matrix enables control over the mechanical microenvironment surrounding cells. Independent tuning of stiffness and stress relaxation uncovers distinct timescales of mechano‐sensing that regulate cell behavior.
Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg   +4 more
wiley   +1 more source

Ice Lithography: Recent Progress Opens a New Frontier of Opportunities

Advanced Functional Materials, EarlyView.
This review focuses on recent advancements in ice lithography, including breakthroughs in compatible precursors and substrates, processes and applications, hardware, and digital methods. Moreover, it offers a roadmap to uncover innovation opportunities for ice lithography in fields such as biological, nanoengineering and microsystems, biophysics and ...
Bingdong Chang, Gwendoline A. E. Anand, Rubaiyet Haque, Dylan A. Chiaro, Mona Sharma, Andrew R. Williams, Frank Niklaus, Daryl W. Yee, Gavin M. King, Anpan Han   +9 more
wiley   +1 more source

A Review on MXene Terminations

Advanced Functional Materials, EarlyView.
Surface terminations play a decisive role in determining the properties of MXenes. Their coordination, composition and stoichiometry can be tuned both during synthesis and through post synthesis methods to tailor MXenes for optimum performance in applications. This review explores the present understanding of surface terminations.
Hari Hara Sudhan Thangavelu, Changjie Huang, Florian Chabanais, Justinas Palisaitis, Per O. Å. Persson   +4 more
wiley   +1 more source