Results 101 to 110 of about 77,933 (256)

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles

iScience
Summary: Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin to produce ceramide—a lipid influencing membrane rigidity and essential for EV generation.
Juan-Carlos A. Padilla, Seda Barutcu, Jonathan Boulais, Janaína Carla da Silva, Yiran Chen, Easin Syed, Eunjeong Kwon, Eric Lécuyer   +7 more
doaj   +1 more source

Three-Dimensional Analysis of Mitochondrial Crista Ultrastructure in a Patient with Leigh Syndrome by In Situ Cryoelectron Tomography

iScience, 2018
Summary: Mitochondrial diseases produce profound neurological dysfunction via mutations affecting mitochondrial energy production, including the relatively common Leigh syndrome (LS).
Stephanie E. Siegmund, Robert Grassucci, Stephen D. Carter, Emanuele Barca, Zachary J. Farino, Martí Juanola-Falgarona, Peijun Zhang, Kurenai Tanji, Michio Hirano, Eric A. Schon, Joachim Frank, Zachary Freyberg   +11 more
doaj   +1 more source

A multi-INT semantic reasoning framework for intelligence analysis support [PDF]

, 2010
Lockheed Martin Corp. has funded research to generate a framework and methodology for developing semantic reasoning applications to support the discipline oflntelligence Analysis. This chapter outlines that framework, discusses
Herbert, Basik, Mike, Dean, Smith, Barry, Terry, Janssen   +3 more
core  

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, EarlyView.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Precursor Mineral Phases of Forming Mollusk Shell Nacre: A Study of Hydrated Samples

Advanced Functional Materials, EarlyView.
Mineral, organic phase, and water are the essential components in mollusk shell nacre formation. Their interplay is not well understood, because the hydrated material is difficult to observe at high resolution, under close to native conditions. Forming nacre is studied using environmental and cryo‐electron microscopy and hydrated ACC phases, together ...
Anna Kozell, Xiao‐Meng Sui, Neta Varsano, Stephen Weiner, Lia Addadi   +4 more
wiley   +1 more source

Colloidal Crack Sintering Lithography for Light‐Induced Patterning of Particle Assemblies

Advanced Functional Materials, EarlyView.
Colloidal crack sintering lithography (CCSL) is a microfabrication technique that uses light‐induced photothermal heating to trigger sintering and controlled cracking in polymer colloidal assemblies. Local structural changes generate microchannels and patterns, enabling direct writing of diverse topographic motifs.
Marius Schoettle, Ariane V. Mader, Willem L. Noorduin   +2 more
wiley   +1 more source

The Rabl configuration limits topological entanglement of chromosomes in budding yeast. [PDF]

, 2019
The three dimensional organization of genomes remains mostly unknown due to their high degree of condensation. Biophysical studies predict that condensation promotes the topological entanglement of chromatin fibers and the inhibition of function.
Arsuaga, Javier, Burgess, Sean, Cruz, Brian, Pouokam, Maxime, Segal, Mark R, Vazquez, Mariel   +5 more
core  

Towards physical principles of biological evolution

, 2018
Biological systems reach organizational complexity that far exceeds the complexity of any known inanimate objects. Biological entities undoubtedly obey the laws of quantum physics and statistical mechanics.
Katsnelson, Mikhail I., Koonin, Eugene V., Wolf, Yuri I.   +2 more
core   +1 more source