Results 81 to 90 of about 16,916 (249)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Protocol for the ADDITION-Plus study : a randomised controlled trial of an individually-tailored behaviour change intervention among people with recently diagnosed type 2 diabetes under intensive UK general practice care. [PDF]

, 2011
Background The increasing prevalence of type 2 diabetes poses both clinical and public health challenges. Cost-effective approaches to prevent progression of the disease in primary care are needed.
Wendy Hardeman, Brage, S, Wareham, Nicholas J, Fanshawe, Thomas R., Williams, Kate M, Williams, KM, Nicholas J Wareham, Grant Julie, Fanshawe Tom, Whittle Fiona, Hobbis, Imogen, Griffin, SJ, Grant, J, Kate M Williams, Grant, Julie, Fanshawe, Thomas, Hobbis, I, Simmons, Rebecca K., Fiona Whittle, Griffin, Simon J, Whittle, F, Westgate Kate, Kinmonth Ann, Wareham Nicholas J, Simon J Griffin, Simmons, Rebecca K, Boase, Sue, Westgate, Kate, Brage Soren, Imogen Hobbis, Sutton, Stephen, Wareham, Nicholas J., Fanshawe, T, Julie Grant, Stephen Sutton, null null, Rebecca K Simmons, Griffin, Simon J., Prevost, A. Toby, Kinmonth, AL, Kate Westgate, Boase Sue, Whittle, Fiona, Prevost A Toby, Williams, Kate M., Williams Kate M, Prevost, A. Toby; id_orcid, Kinmonth, Ann Louise, Sutton Stephen, Westgate, K, Hardeman, Wendy, Boase, S, Fanshawe, Tom, Tom Fanshawe, Soren Brage, Prevost, A Toby, Ann Louise Kinmonth, Hobbis Imogen, Simmons Rebecca K, team, ADDITION-Plus study, A Toby Prevost, Simmons, RK, Sutton, S, Brage, Soren, Griffin Simon J, Sue Boase, Hardeman, W, Wareham, NJ, Prevost, AT, Hardeman Wendy   +69 more
core   +4 more sources

Når arbeidet blir skole og skolen blir arbeid – #Læringslivet som et eksempel på et symbiotisk læringssystem

Forskning og Forandring, 2018
Medarbeiderdrevet innovasjon (MDI) (Høyrup, 2010, 2012) kan relateres til uformell læring og kollektiv organisatorisk læring basert på bred deltakelse i utviklingsarbeid på arbeidsplassen (Herbst 1993a, b; Eikeland, 2012a). I aksjonsforskningsprosjektet #
Nina Amble, Else Marie Johansen
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Exploring the generative AI potential in the fashion design process: an experimental experience on the collaboration between fashion design practitioners and generative AI tools

European Journal of Cultural Management and Policy
Over recent years, the rise of Generative Artificial Intelligence (Gen AI) has led to the emergence of numerous tools for the creation of visual and textual content. This technological advancement, supported by increasingly robust data management systems
Greta Rizzi, Paola Bertola
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Knowledge co-creation in arts universities: the role of entrepreneurial mindset and communities of practice

European Journal of Cultural Management and Policy
This article examines how an entrepreneurial mindset can act as a facilitator of knowledge management and co-creation within arts universities through the lens of Communities of Practice (CoPs). While entrepreneurial education in the arts is often framed
Kristina Kuznetsova-Bogdanovitsh, Anna Maria Ranczakowska   +1 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Leg og det legende i højere uddannelse? – En legekvalitetsanalyse af 36 didaktiske designs på pædagog- og læreruddannelsen

Forskning og Forandring
Denne artikel undersøger beskrivelser af didaktiske designs, som undervisere på pædagog- og læreruddannelsen i Danmark har lavet som led i deres arbejde med legende tilgange til deres undervisning.
Helle Marie Skovbjerg, Helle Hovgaard Jørgensen   +1 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source