Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Leading Organizational Change in the Post-COVID Pandemic Era. [PDF]
J Public Health Manag Pract, 2023 Baker EL, Musselwhite C.
europepmc +1 more source
ORGANIZATIONAL CHANGE- DIFFERENT APPROACHES [PDF]
As organizations decide to expand on other markets, managers are facing with new problems and realities. If thirty years ago, companies afford to ignore the international business environment, today they need to think globally.
Georgiana Surdu
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
"Tell me and I forget, teach me and I may remember, involve me and I learn": changing the approach of teaching Computer Organization [PDF]
, 2017 Matías Lopez‐Rosenfeld
openalex +1 more source
The Implications of Information and Communication Technology and of Emotional Intelligence within Organizations [PDF]
Lately people say more and more about emotional intelligence, about knowledge based economy, about intangible assets and intellectual capital. The permanent improvement of the knowledge supply will be decisive for reaching the success.
Aurelia STANESCU, Florea PÎRVU
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Analysis of the Organizational Eco-Systemic Change in a Cooperative Society of Fishing Production
, 2016 Vargas Hernández JG +2 more
openalex +1 more source
Four Essays on Technological and Organizational Change in Health Care [PDF]
, 2004 This thesis contains four essays on technological and organizational change in health care. Although each chapter can be read independently, there is a central thread resumed in each chapter.
Selder, Astrid
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source