Results 51 to 60 of about 3,553,762 (351)

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source

The relation of social capital and organizational justice with organizational commitment based on structural equation model among female high school teachers in Isfahan in 2011-12 [PDF]

رویکردهای نوین آموزشی, 2012
The purpose of this research was to study the relationship of social capital and organizational justice with organizational commitment. The population was all female high school teachers in Isfahan, that among them 358 were selected via clustered random ...
Mohammad Ali Nadi, Hossein Molavi, B. Toghraee   +2 more
doaj  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

The Effect of Organizational Cynicism on Organizational Commitment among Nurses

Sağlık ve Hemşirelik Yönetimi Dergisi, 2020
INTRODUCTION: This study was conducted to examine the effect of organizational cynicism on organizational commitment on nurses. METHODS: The descriptive and relationship-seeking and cross-sectional study was conducted between January 2018 and June 2019 ...
Yeşim Biçici, Sevgi Nehir
doaj   +1 more source

Komitmen Organisasi Staf Jurnal Indonesia berdasarkan Komunikasi, Kepemimpinan, dan Etika Kerja

Jurnal Komunikasi, 2023
Increasing the organizational commitment of employees or staff is one way to increase organizational performance so that it remains competitive and resilient.
Faraz, Anggi Arif Fudin Setiadi, Elfrida Khoerunnisa, Firdaus Algim Nastiyar   +3 more
doaj   +1 more source

The Effect of Organizational Support on Organizational Commitment

The Anthropologist, 2014
This research examines the effect of organizational support for teachers on their organizational commitment. The data was collected from 819 primary school teachers in seven cities from every geographical regions of Turkey. In the research, the two scales administered are "Perceived Organizational Support Scale (POSS)" and "Teachers' Organizational ...
openaire   +2 more sources

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

TOrganizational learning and the effect on organizational commitment among employees and managers at Razi University in Kermanshah [PDF]

Pizhūhish/hā-yi rahbarī va mudīriyyat-i āmūzishī, 2016
This study examines the impact of organizational learning on organizational commitment of staff and managers are Razi University in Kermanshah. The study is cross correlation.
Ehsan Parvin, Mohammad Reza Kargozari
doaj   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source