Results 71 to 80 of about 4,842,709 (257)

Competence Development and Affective Commitment as Mechanisms That Explain the Relationship between Organizational Culture and Turnover Intentions

Administrative Sciences
This study investigated the effect of organizational culture (supportive culture, innovation culture, goal culture and rule culture) on turnover intentions and whether this relationship was mediated by organizational practices of competencies development
Ana Palma-Moreira, Ana Lúcia Dias, Beatriz Pereira, Manuel Au-Yong-Oliveira   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Issues of standardization concerning organizational culture in change management [PDF]

This paper is a challenge in taking another view on cultural elements, considered to be more specific then any other strategic issues of management. The paper is structured into the following parts: cultural dimensions and variables; barriers to the ...
Doval, E, Doval, O
core  

Examining the Functioning of Organizations from the Aspects of Organizational Culture and Leadership

International Journal of Engineering and Management Sciences, 2018
Organizational culture and Leadership both have been under research for a long time, as they play a vital role in the performance of an organization. The organizational culture is the set of rules or acts as a guidebook of an organization for achieving ...
Ridhi Awasthi, Syed Mansub Ali
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Linking transformational leadership and organizational culture

, 1996
Many authors assume a strong relationship between culture and leadership in organizations. Leaders create, transform and manage organizational cultures. Although this linkage between organizational culture and leadership is often referred to, hypotheses ...
van Meijen, J.J., Koopman, P.L., den Hartog, D.N.   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Organizational Citizenship Behavior and Turnover Intentions: Do Organizational Culture and Justice Moderate Their Relationship?

, 2011
The hypothesized moderating effects of the dimensions of organizational justice and organizational culture on the relationship of organizational citizenship behaviour (OCB) and turnover intentions were examined.
Aharon Tziner, Keren Shaul, Lian Zilberman, Shaul, Keren, Tamar Shultz, Sharoni, Gil, Gil Sharoni, Zilberman, Lian, Tziner, Aharon, Erich C. Fein, Fein, Erich C., Shultz, Tamar   +11 more
core   +1 more source

Representation a Model of Organizational Culture Management with Contextual Approach (Case Study: An Industrial Company)

جامعه شناسی کاربردی, 2011
The purpose of this article is representation a model of organizational culture in an industrial company with contextual approach in diagnostic of present and desire organizational culture and suggestions about organizational culture change for obtain ...
Mohammadesmaeil Ansari, Ali Shaemi Barzoki, Ali Safari   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source