Results 81 to 90 of about 4,842,709 (257)

Adaptations of a Global Organizational Culture in China, the UK and the US: Does Social Culture Make Any Difference? [PDF]

, 2010
[[abstract]]This research examined the extent to which organizational subunits of a single organization adapted the organizational culture to different social cultural contexts, and the implications of such adaptations on individual level outcomes ...
CATHERINE T. KWANTES, BEN C. H. KUO, CHERYL A. BOGLARSKY   +2 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Methodology for determining influence of organizational culture to business performance

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2007
Content this article is to propose the possible methodology for quantitative measuring the organizational culture using the set of statistical methods. In view of aim we elected procedure consisting of two major sections.
Eva Skoumalová, Bohumil Minařík
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Situation of Organizational Culture and its Relationship with Organizational Commitment and Entrepreneurial Potential in Selected Hospitals of Shiraz University of Medical Sciences in 2015-2016

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2017
Background: The operation of an organization can be improved by organizational culture and commitment. Further, culture is one of the most basic tools for development of entrepreneurial.
Razieh Montazeralfaraj, Milad Shafii, Zeinab Manzouri   +2 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

ORGANIZATIONAL CULTURE: KEY ISSUES. A LITERATURE REVIEW [PDF]

Annals of the University of Oradea: Economic Science, 2017
In the today's global, knowledge-based digital economy, the organizational culture becomes a strategic source of sustained competitive advantage. Therefore, the organizational culture is an increasingly important issue of academic research, education ...
Ilies Liviu, Metz Daniel
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Organizational Culture through Orientations and Metaphors: Some Hints to the Tacit Knowledge [PDF]

The main goal of our study is to examine the possibilties to lead tacit through a lens of organizational culture assessed by orientations and metaphors. Organizational culture may open important issues because this phenomenon evolves values, assumptions ...
Maaja VADI, Gerli HAMMAL
core  

ENTERPRISE AND ORGANIZATIONAL CULTURE [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2010
Environmental adaptation and behavioral integration are two major problems the organization of this beginning of century is confronting with. Organizational culture is one of the solutions to solving these problems.
DORU CÎRNU , Amelia BONCEA
doaj