Results 101 to 110 of about 5,005,544 (308)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Organizational Culture and Ethics Work Satisfaction
, 1995 Nurse executives have opportunities for creating constructive organizational cultures and for supporting ethical healthcare practice. Because culture and ethics are so central to effective nursing practice, this study explored relationships between them,
McDaniel, Charlotte
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
The key role of organizational culture in a multi-system view of technology-driven change. [PDF]
Organizations undergoing technology-driven change must understand that technology is only one of several inter-related components which drive organizational performance. A multi-system perspective of organizations highlights the interdependencies between
Cabrera, Elizabeth F. +2 more
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Research in Organizational Culture [PDF]
مطالعات مدیریت بهبود و تحول, 2004 فرهنگ سازمانی یکی از موضوعات مورد علاقه نویسندگان و پژوهشگران رشته مدیریت در دهه های اخیر بوده است. پژوهش های زیادی در این زمینه انجام شده و مقالات و کتب متعددی به رشته تحریر در آمده اند که از گونه گونی بسیار در مبانی نظری، اهداف و روش ها برخوردار می ...
seyed mohammad zahedi
doaj
Organizational culture putting the organizational culture concept to work.
The Behavior Analyst Today, 2003 The concept of organizational culture (OC) is a potential candidate for every organizational psychologist's conceptual toolbox. Organizational clients consider OC to be critical for recruiting and retaining employees, and academic literature on the topic implicates cultural variables as being highly relevant during organizational change initiatives ...
openaire +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Developing the Organizational Culture [PDF]
Revista de Management Comparat International, 2015 In the new economy, organizations face a number of challenges that leaders will have to find answers to and for which the knowledge-based leadership can be an important part of the solutions that are identified.
Geantă SERGIU
doaj
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Cross-cultural validation of the Intensity & Strength Organizational Culture Questionnaire.
, 2012 In the final presentation, Laura Petitta, Claudio Barbaranelli, and Tahira Probst address the relevance of capturing organizational culture complexity for effective managerial action and intervention. They present findings of a cross-cultural validation
PETITTA, LAURA +2 more
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