Results 91 to 100 of about 3,791,843 (294)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
DIAGNOZA POTENȚIALULUI MANAGERIAL AL INSTITUȚIEI PUBLICE
Buletinul Științific al Universității de Stat „B.P. Hasdeu” din Cahul: Științe SocialeThe article explores the detailed analysis of the public institution, focusing on the evaluation of the organizational structure and decision-making processes, alongside the analysis of the organizational culture, ethics and human resources management ...
Grațian-Daniel GOLOȘIE +1 more
doaj +1 more source
Production, 2009 Este trabalho se insere no campo de pesquisa em estratégia organizacional e apresenta uma revisão e análise comparativa dos modelos de alinhamento estratégico. A relevância deste estudo está relacionada à importância da execução da estratégia no contexto
Vanderli Correia Prieto +2 more
doaj +1 more source
AMCP's new election process: Designed for organizational effectiveness. [PDF]
J Manag Care Spec Pharm, 2023 Cantrell SA, Hopsicker JR, Curry D.
europepmc +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
, 2010 The literature suggests that the dynamics prevailing in an internal audit (IA) milieu possibly influence internal audit effectiveness. Besides organizational attributes that appear to influence IA effectiveness, other factors grounded in country context ...
Mihret, Dessalegn Getie
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Towards an Integrated Framework for Corporate Entrepreneurship
Problemy Zarządzania, 2016 Drawing on a resource-based perspective as well as strategic entrepreneurship theory, this empirical study examines how the performance effect of corporate entrepreneurship is mediated by firm strategy and task contingency regarding key environmental ...
Katarzyna Bratnicka +1 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
National Clinical Effectiveness Committee annual report 2013
, 2014 The National Clinical Effectiveness Committee (NCEC) was established as part of the Patient Safety First Initiative in September 2010. The NCECs mission is to provide a framework for national endorsement of clinical guidelines and audit to optimise ...
National Clinical Effectiveness Committee
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