Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Do they really coexist? An empirical analysis of a conjoint implementation of Quality Management System and High Performance Work System on organizational effectiveness. [PDF]
PLoS One, 2020 Rehmani K, Ahmad Y, Naseem A, Syed TH.
europepmc +1 more source
Organizational Commitment and Organizational Effectiveness
Management Dynamics, 2022 openaire +1 more source
A contingency model of perceived effectiveness in accounting information systems: Organizational coordination and control effects [PDF]
, 2000 A contingency model is advanced that examines sources of requirements for organizational coordination and control as they affect the extent of integration in an accounting information system.
Nicolaou, Andreas I
core
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Pengaruh Struktur Organisasi Terhadap Efektivitas Organisasi (Studi Pada Persepsi Pegawai Tetap Kantor Perwakilan Bank Indonesia Kediri) [PDF]
, 2014 The results showed that the organizational structure dimension consisting of complexity, formalization, centralizationvariables together effect on organizational effectiveness.
Gammahendra, F. (Fianda)
core
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
Organizational culture in shaping organizational effectiveness [PDF]
Studia i Prace WNEiZ, 2016 Ewa Stroińska, Justyna Trippner-Hrabi
openaire +1 more source
, 2004 Work teams are composed of two or more individuals; who exist to perform organizationally relevant tasks; share one or more common goals; interact socially; exhibit interdependencies in task workflows, goals, and/or outcomes; maintain and manage ...
Bell, Bradford S, Kozlowski, Steve W. J.
core +1 more source