Results 131 to 140 of about 157,953 (310)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Virtual Organizational Learnign in Open Source Software Development Projects [PDF]

open access: yes
We studied the existence of virtual organizational learning in open source software (OSS) development projects. Specifically, our research focused on learning effects of OSS projects and factors that affect the learning process. The number and percentage
Darrell Carpenter   +3 more
core  

Understanding the culture and climate underpinnings of organizational effectiveness. [PDF]

open access: yes, 2012
It is widely recognized that organizational culture and climate play a central role in strategic choices made by the management that can result in competitive advantage (e.g., see Barney, 1986; Lim, 1995; Schein, 2004).
PETITTA, LAURA
core  

Weathering the storm: A case study of organizational culture and effectiveness in times of disruptive jolts and crisis [PDF]

open access: yes
A crisis stems from an unexpected negative change in the environment, threatening the high-priority values of the organization. As a crisis, the COVID-19 pandemic jolted businesses worldwide, necessitating an investigation into the aspects of such an ...
Zandi, F., Mokhtarifar, R., Nazarian, A.
core   +1 more source

Navigating works future: Harnessing digital innovation to enhance muslim employees performance through transformation and flexibility

open access: yesJema: Jurnal Ilmiah Bidang Akuntansi dan Manajemen
Fierce competition and uneven quality of service have made higher education institutions face pressure to undergo digital transformation and increase human resource performance.
Usep Deden Suherman   +3 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Organizational Effectiveness Literature Review [PDF]

open access: yes, 2000
Provides an overview and analysis of recent literature related to organizational effectiveness and management in nonprofit organizations.
Julia Davis
core  

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Career effectiveness and its determinants [PDF]

open access: yes
Study of careers has become an important aspect in the fast changing organizational context. It has come to be increasingly recognized at present, that career management is the responsibility of both the individual as well as the organization.
Maheshwari, Sunil Kumar, Krishnan T N
core  

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