Results 51 to 60 of about 250,197 (262)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Providing scientific model of transparency regarding institutional and organizational loyalty with emphasis on the mediating role of organizational trust of employees of Medical Sciences [PDF]

open access: yesPizhūhish/hā-yi rahbarī va mudīriyyat-i āmūzishī, 2017
Methods: The research method is descriptive - correlation. The study population comprised 630 employees, Zahedan University of Medical Sciences. For this purpose, using a random sample of 187 personal was selected.
گل افروز رمضانی   +2 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Impact of team coaching on organizational results : a longitudinal approach

open access: yesInternational Journal of Evidence Based Coaching and Mentoring
This study aims to explore the impact of team coaching on organizational outcomes. To achieve this, a mixed-method approach integrating action research and longitudinal evidence of quantitative business indicators is employed.
Fernández-Llano, César   +2 more
doaj   +1 more source

IMPROVING PUBLIC SERVICES THROUGH A ORGANIZATIONAL PERFORMANCE MANAGEMENT [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2010
Organizational management, systemic approach, is known more as a system Management, that set of factors such as organizational, methodological information, decisions and relationships between them, as outlined, that will achieve objectives.
IOANA STĂNCESCU   +3 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Management Development in Iranian Academic Libraries: Performances and Obstacles

open access: yesInternational Journal of Information Science and Management, 2013
This paper aims to investigate the current status of management development in academic libraries and it identifies the deterrent factors in administering management development programs.
Nilofar Barahmand, Zouhayr Hayati
doaj  

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Role of Authentic Leadership and Teachers’ Organizational Commitment on Organizational Citizenship Behavior in Higher Education

open access: yesInternational Journal of Educational Leadership and Management, 2021
Several studies highlight the significant role of authentic leadership and followers' organizational commitment on organizational citizenship behavior in business organizations.
Ma. Celia T. Roncesvalles   +1 more
doaj   +2 more sources

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