Results 51 to 60 of about 33,490 (268)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Critical analysis of the implications of new managerialism on ethical, democratic and professional values in public service

Redes, 2016
This paper aims to critically analyze the implications of the new managerialism in the public service through ethical, democratic and professional values.
Jose G. Vargas-Hernández
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

ARE THERE SUCH THINGS AS THEORIES OF TRAINING EQUALLY COMPARABLE TO THEORIES OF LEARNING? LITERATURE REVIEW

Jurnal Sosial Humaniora, 2015
This article provides a literature review on the comparison between theories of learning and theories of training. Despite their equally vital roles in the improvement of human capital quality, it turns out that almost all of the training theories have ...
Fuad Cholisi
doaj   +1 more source

Organizational Learning – Desperately Seeking Theory?

, 1999
Concepts of organizational learning abound in the literature. There has been an increasing diversity of attempts at classification, but an integrated theory is still missing. To provide some tentative answers as to why theory development in organizational learning has made such little progress, a number of requirements for theory-building will be ...
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

New Ideas about Leadership at Work in the Workplace

Revista Transilvană de Ştiinţe Administrative, 2002
This study examines the impact of managerial leadership theories on the way mangers in organizations across US perceive and define their organizational performance. The analysis focuses on the model of managerial efficiency described by the open systems,
Mirela NEMEȘ
doaj  

Absorptive capacity in organizational theories: learning, innovation, managerial cognition [PDF]

Marketing i Menedžment Innovacij, 2013
The paper studies an important issue of absorptive capacity that enables the companies to strengthen their position in the competitive global market.
O.A. Vasylieva
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

A Glance at Terrorist Organizations from the Perspective of Organizational Theories

Cumhuriyet Üniversitesi İktisadi ve İdari Bilimler Dergisi, 2013
The problem of conceptualizing terrorist organization is still a controversial issue, even though it has been taken place in the literature heavily.
Sefer Yılmaz
doaj