Results 91 to 100 of about 10,956 (235)

Cooperative effects between arginine and glutamic acid in the amino acid catalyzed aldol reaction [PDF]

, 2017
Catalysis of the aldol reaction between cyclohexanone and 4-nitrobenzaldehyde by mixtures of L-Arg and of L-Glu in wet DMSO takes place with higher enantioselectivity (up to a seven-fold enhancement in the anti- aldol for the 1:1 mixture) than that ...
Moyano i Baldoire, Albert, Valero González, Guillem   +1 more
core   +1 more source

Asymmetric organocatalysis involving double activation

Tetrahedron Chem, 2022
Asymmetric organocatalysis contributed tremendously to the field of organic synthesis since year 2000. Considering the diversity of organocatalysts and their activation modes, chemists developed the double activation strategy, in which two distinct ...
Zhi Chen, Qian-Qian Yang, Wei Du, Ying-Chun Chen   +3 more
doaj  

Indirect Anti-Markovnikov Hydrofunctionalization of Terminal Alkenes via an Alkenyl Thianthrenium Intermediate. [PDF]

Angew Chem Int Ed Engl
A two‐stage dication pool strategy using alkenyl thianthrenium intermediates has been developed for anti‐Markovnikov hydrofunctionalization. This method differs from previous approaches in its reaction mechanism and addresses their most significant limitation, namely, the restricted generality of the nucleophile. The approach has been extended to other
Sóvári B, Angyal P, Babcsányi IJ, Kotschy AM, Dudás Á, Turczel G, Varga S, Soós T.   +7 more
europepmc   +3 more sources

A bifunctional photoaminocatalyst for the alkylation of aldehydes: Design, analysis, and mechanistic studies [PDF]

, 2018
This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Catalysis, copyright ©2018 American Chemical Society after peer review and technical editing by the publisher.
Alemán, José, Cabrera, Silvia, Casado-Sánchez, Antonio, De La Peña O'Shea, Víctor A., Liras, Marta, Pérez-Ruiz, Raúl, Rigotti, Thomas   +6 more
core   +5 more sources

Asymmetric Synthesis of Propargylic and Allenic Silanes, Germanes, and Stannanes

Chemistry – An Asian Journal, EarlyView.
Organotetrel compounds are important reagents with broad applications in chemical industries and natural product synthesis. This review provides a summary of strategies for the synthesis of propargylic and allenic organotetrels in their enantioenriched forms.
Hai Chang, Ruihan Wang, Yi‐Ming Wang
wiley   +1 more source

Mechanical force-switchable aqueous organocatalysis

Communications Materials
Control over the catalytic activity of artificial catalytic systems in aqueous media is of high interest for biomimetic artificial catalysts. The activity of catalytic systems can be controlled via introducing stimuli-responsive feature in the structure ...
Nikita Das, Chandan Maity
doaj   +1 more source

Recent Advances in Sustainable Organocatalysis [PDF]

, 2016
The recent advances on green and sustainable organocatalysis are revised in this chapter. An important focus on one of the 12 principles of green chemistry, organocatalysis pursues to reduce energy consumption as well as to optimize the use of different ...
Branco, Luis C., Branco, Paula S., Faisca Phillips, Ana M., Gago, Sandra, Marques, Maria M.   +4 more
core   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

“Dial Up and Lock In”: Asymmetric organo-Brønsted acid catalysis incorporating stable isotopes [PDF]

, 2016
An operationally simple organo-Brønsted-acid-catalyzed asymmetric and regioselective “dial up and lock in” of one or more stable isotopes into organic compounds is unknown.
Bachera, Dominika U., Bew, Sean P., Coles, Simon J., Hiatt-Gipson, Glyn D., Pesce, Paolo, Pitak, Mateusz, Thurston, Sean M., Zdorichenko, Victor   +7 more
core   +1 more source

Hijacking the MDM2 E3 Ligase with novel BRD4‐Targeting PROTACs in Pancreatic Cancer Cells

ChemBioChem, Accepted Article.
The phenotypic effect induced by a Proteolysis‐Targeting Chimera (PROTAC) can depend on several factors, including the E3 ligase recruited. For the discovery of a first‐in‐class PROTAC for a target of interest, the E3 ligases commonly hijacked remain the Von Hippel‐Lindau (VHL) and Cereblon (CRBN) since potent and accessible ligands are readily ...
Mihaela Ficu, Dan Niculescu-Duvaz, Mohammed Aljarah, Caroline Springer, Christopher S. Kershaw   +4 more
wiley   +1 more source