Results 71 to 80 of about 8,155 (194)

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Recent advances in organocatalytic atroposelective reactions

Beilstein Journal of Organic Chemistry
Axial chirality is present in a variety of naturally occurring compounds, and is becoming increasingly relevant also in medicine. Many axially chiral compounds are important as catalysts in asymmetric catalysis or have chiroptical properties. This review
Henrich Szabados, Radovan Šebesta
doaj   +1 more source

Modular Synthesis of α‐Quaternary Pyrrolines by Pyridoxal‐Catalyzed Sequential Reactions With Precise Chirality Relay

Transformative Chemistry, EarlyView.
Direct asymmetric α‐C conjugate addition of aminoacetonitrile enabled by carbonyl/iminium double activation, together with subsequent electrophilic functionalization, offers a one‐pot, two‐step modular strategy for synthesizing chiral α‐quaternary pyrrolines with precise chirality relay and high structural diversity.
Xingdie Yang, Pengwei Ji, Liang Liu, Tongyin Chen, Siqi Liu, Wen‐Wen Chen, Baoguo Zhao   +6 more
wiley   +1 more source

Enantioselective Organocatalysis and Superacid Activation: Challenges and Opportunities

, 2023
International audienceSince the pioneer reports of Akiyama and Terada groups on Brønsted acid organocatalysis, this field never stopped growing with the development of ingenious strategies for the activation of challenging poorly reactive substrates. The
Bastien Michelet, Agnès Martin‐Mingot, Martin-Mingot, Agnès, Thibaudeau, Sébastien, Jean Rodriguez, Sébastien Thibaudeau, Damien Bonne, Rodriguez, Jean, Michelet, Bastien, Bonne, Damien   +9 more
core   +1 more source

Chiral phosphines in nucleophilic organocatalysis

Beilstein Journal of Organic Chemistry, 2014
This review discusses the tertiary phosphines possessing various chiral skeletons that have been used in asymmetric nucleophilic organocatalytic reactions, including annulations of allenes, alkynes, and Morita–Baylis–Hillman (MBH) acetates, carbonates ...
Yumei Xiao, Zhanhu Sun, Hongchao Guo, Ohyun Kwon   +3 more
doaj   +1 more source

Selective Chain Scission of L‐Lactide/ε‐Caprolactone Chain Shuttled Copolymers

ChemSusChem, Volume 19, Issue 21, 12 November 2026.
L‐lactide/ε‐caprolactone chain shuttled multiblock copolymers are composed of PLLA‐rich hard blocks and poly(ε‐caprolactone‐co‐L‐lactide) soft blocks. They can be selectively degraded, notably into PLA oligomers, by organocatalyzed transesterification. This allows not only to determine the block length but also to envision the recycling of the PLA part
A. Noon, L. Fichaux, X. Mosca, P. A. Lowy, T. Bousquet, L. Pelinski, F. Bonnet, J. P. P. Ramalho, A. Favrelle‐Huret, P. Zinck   +9 more
wiley   +1 more source

2.8 Recent Advances in N-Heterocyclic Carbene Organocatalysis

, 2018
In recent years, organocatalysis has seen a rapid rise in popularity and this has led to a subsequent increase in the research output of the area, with organocatalysis by N-heterocyclic carbenes (NHCs) playing a significant role.
A. Davies, A. D. Smith
core   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 6, Page 1798-1823, November 2026.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, Volume 29, Issue 40, 27 October 2026.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Catalytic Strategies for Amide-Based Michael Additions: Advances and Perspectives

Journal of Chemistry
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β-unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α ...
Muhammad Naufal, Elvira Hermawati, Ace Tatang Hidayat, Dadan Sumiarsa, Ika Wiani Hidayat, Jamaludin Al-Anshori   +5 more
doaj   +1 more source