Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications
Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff +2 more
wiley +1 more source
Poly(ethylene glycol)-supported ααα-trifluoroacetophenone in dioxirane mediated alkene epoxidation reactions [PDF]
, 2004 Poly(ethylene glycol) (PEG) was used for the immobilization of ααα-trifluoroacetophenone and the utility of this supported ketone has been examined in dioxirane mediated epoxidation of alkenes.
Kan, JTW, Toy, P
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Catalytic Strategies for Amide-Based Michael Additions: Advances and Perspectives
Journal of ChemistryThe Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β-unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α ...
Muhammad Naufal +5 more
doaj +1 more source
How cinchona alkaloid-derived primary amines control asymmetric electrophilic fluorination of cyclic ketones. [PDF]
, 2014 The origin of selectivity in the α-fluorination of cyclic ketones catalyzed by cinchona alkaloid-derived primary amines is determined with density functional calculations.
Houk, KN, Lam, Yu-hong
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Mechanical force-switchable aqueous organocatalysis
Communications MaterialsControl over the catalytic activity of artificial catalytic systems in aqueous media is of high interest for biomimetic artificial catalysts. The activity of catalytic systems can be controlled via introducing stimuli-responsive feature in the structure ...
Nikita Das, Chandan Maity
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Acid‐Catalyzed Synthesis of Si‐Stereogenic Silanes
Chinese Journal of Chemistry, Volume 44, Issue 8, Page 1212-1222, 15 April 2026.Si‐stereogenic silanes are important structural motifs in chemical synthesis, medicinal chemistry, and materials science. However, their catalytic enantioselective synthesis has largely relied on transition‐metal catalysts. Recently, Brønsted acids have been developed as promising alternatives.
Jung Tae Han, Benjamin List
wiley +1 more source
Ruthenium Olefin Metathesis Catalysts Bearing Carbohydrate-Based N-Heterocyclic Carbenes [PDF]
, 2010 Ru-based olefin metathesis catalysts containing carbohydrate-derived NHCs from glucose and galactose were synthesized and characterized by NMR spectroscopy. 2D-NMR spectroscopy revealed the presence of Ru−C (benzylidene) rotamers at room temperature, and
Grubbs, Robert H., Keitz, Benjamin K.
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Annual Reports Section "B" (Organic Chemistry), 2011 Benjamin R. Buckley, Mohamed M. Farah
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“Dial Up and Lock In”: Asymmetric organo-Brønsted acid catalysis incorporating stable isotopes [PDF]
, 2016 An operationally simple organo-Brønsted-acid-catalyzed asymmetric and regioselective “dial up and lock in” of one or more stable isotopes into organic compounds is unknown.
Bachera, Dominika U. +7 more
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Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
Molecules, 2013 The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations.
Isidro M. Pastor +3 more
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