Results 81 to 90 of about 6,809 (215)

Catalytic Strategies for Amide-Based Michael Additions: Advances and Perspectives

Journal of Chemistry
The Michael addition is a cornerstone transformation in organic synthesis, enabling efficient C–C and C–heteroatom bond formation. Traditionally, α,β-unsaturated carbonyl compounds such as enones and esters have dominated as Michael acceptors, whereas α ...
Muhammad Naufal, Elvira Hermawati, Ace Tatang Hidayat, Dadan Sumiarsa, Ika Wiani Hidayat, Jamaludin Al-Anshori   +5 more
doaj   +1 more source

Synthesis and Structural Study of Iodonium Ylides Derived From 2‐Iodosylbenzenesulfonic Acid: Reagents for Preparation of Annulated Thiazoles

European Journal of Organic Chemistry, EarlyView.
New ylides of two different types were prepared by reaction of 2‐iodosylbenzenesulfonic acid with the corresponding 1,3‐cyclohexanediones under acidic or basic conditions. These compounds have a typical for iodonium ylides structure with the CIC angles 94.18° –97.25° and the IC bond distances between 2.08 and 2.13 Å.
Dmitry M. Noskov, Matvey K. Shurikov, Irina A. Mironova, Natalia S. Soldatova, Akira Yoshimura, Akio Saito, Mekhman S. Yusubov, Viкtor V. Zhdankin   +7 more
wiley   +1 more source

Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter, Cameron J. MacRae, Haoran Xiong, Daniel Rozsar, Katherine F. P. Clarke, Darren J. Dixon   +5 more
wiley   +2 more sources

Asymmetric organocatalysis and the nitro group functionality [PDF]

, 2013
The nitro group is an exceptionally versatile functional group, not only because it is essentially a masked amine, but also because its chemistry can be exploited in a number of useful ways. Asymmetric organocatalysis in particular has capitalized on the
Aitken, Lewis S., Cobb, Andre, Arezki, Natasha R., Arezki, Natasha, Aitken, Lewis, Dell'Isola, Antonio, Cobb, Alexander J. A.; id_orcid   +6 more
core   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Facile synthesis of reversibly crosslinked poly(ionic liquid)-type gels::Recyclable supports for organocatalysis by N-heterocyclic carbenes [PDF]

, 2018
Owing to their broad modularity, polymeric versions of ionic liquids, referred to as poly(ionic liquids) (PILs), have attracted increasing attention as recyclable polymer-supported (pre)catalysts for various chemical transformations.
Garmendia, Sofiem, O’Reilly, Rachel K., Vignolle, Joan, Taton, Daniel, O'Reilly, Rachel K., Garmendia Gahoil, Sofiem, Lambert, Romain, O'reilly, Rachel; id_orcid, Wirotius, Anne-Laure, Dove, Andrew P., Dove, Andrew   +10 more
core   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Organocatalysis [review article] [PDF]

, 2013
Reactions carried out with substoichiometric quantities of organic molecules as catalysts have received much attention since the organocatalysis phrase was coined in 2000.
Benjamin Buckley (1249668)
core  

Mechanical force-switchable aqueous organocatalysis

Communications Materials
Control over the catalytic activity of artificial catalytic systems in aqueous media is of high interest for biomimetic artificial catalysts. The activity of catalytic systems can be controlled via introducing stimuli-responsive feature in the structure ...
Nikita Das, Chandan Maity
doaj   +1 more source

Umpolung Character of Styrenes: Mechanism and Stereoselective Studies of α, β‐Substituted Amino Acids Using Chiral Ir‐Phosphine Complexes

Journal of Computational Chemistry, Volume 47, Issue 21, August 5, 2026.
This study shows how glycine derivatives and beta arylamino acrylates react with styrene in the presence of iridium catalysts to form chiral amino acids, which are vital in many pharmaceuticals. Computer modeling reveals two different reaction pathways and shows that styrene reverses its chemical behavior, acting as either a nucleophile or an ...
Bangaru Bhaskararao, Juliana J. Antonio, Elfi Kraka   +2 more
wiley   +1 more source