Results 81 to 90 of about 6,799 (217)

Facile synthesis of reversibly crosslinked poly(ionic liquid)-type gels::Recyclable supports for organocatalysis by N-heterocyclic carbenes [PDF]

, 2018
Owing to their broad modularity, polymeric versions of ionic liquids, referred to as poly(ionic liquids) (PILs), have attracted increasing attention as recyclable polymer-supported (pre)catalysts for various chemical transformations.
Garmendia, Sofiem, O’Reilly, Rachel K., Vignolle, Joan, Taton, Daniel, O'Reilly, Rachel K., Garmendia Gahoil, Sofiem, Lambert, Romain, O'reilly, Rachel; id_orcid, Wirotius, Anne-Laure, Dove, Andrew P., Dove, Andrew   +10 more
core   +1 more source

Synthesis of Benzopyran Atropisomers via Electrophilic Halogenation

European Journal of Organic Chemistry, EarlyView.
We report a halogenation‐based method for the synthesis of axially chiral benzopyrans, tolerating diverse substituents and halogens (Br, Cl, and I). A double bromination gives bisbenzopyrans with two stereogenic axes. Preliminary enantioselective conditions yield benzopyran atropisomer with up to 56% ee.
Alix Bourhis, Expédite Yen‐Pon, Jean Rodriguez, Damien Bonne   +3 more
wiley   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Diverse reactivity of maleimides in polymer science and beyond

Polymer International, Volume 74, Issue 4, Page 296-306, April 2025.
This mini‐review provides a thorough overview of maleimide chemistry, highlighting its diverse reactivity in polymer and materials science applications. Abstract Maleimides are remarkably versatile functional groups, capable of participating in homo‐ and copolymerizations, Diels–Alder and (photo)cycloadditions, Michael additions, and other reactions ...
Bruce E Kirkpatrick, Kristi S Anseth, Tayler S Hebner   +2 more
wiley   +1 more source

Synthesis of Polyurethanes Using Organocatalysis: A Perspective

, 2015
Organocatalysis has become an invaluable tool for polymer synthesis, and its utility has been demonstrated in ring-opening, anionic, zwitterionic, and group-transfer polymerizations.
Haritz Sardon, MECERREYES, David, SARDON, Haritz, HEDRICK, James L., PASCUAL, Ana, Henri Cramail, James L. Hedrick, CRAMAIL, Henri, Ana Pascual, David Mecerreyes, Daniel Taton, TATON, Daniel   +11 more
core   +1 more source

Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis

Molecules, 2013
The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations.
Isidro M. Pastor, Diego A. Alonso, Beatriz Maciá, M. Ángeles Fernández-Ibañez   +3 more
doaj   +1 more source

Diastereo- and Enantioselective Direct Aldol Reactions in Aqueous Medium: a New Highly Efficient Proline-Sugar Chimeric Catalyst

, 2011
Synthesis and successful applications in terms of chemical yields and diastereo-/enantiomeric ratios of a new catalyst in the DAA of cyclohexanone and acetone to variously substituted benzaldehydes have been ...
CAPUTO, ROMUALDO, DE NISCO, MAURO, PEDATELLA, SILVANA, Nucci A.   +3 more
core  

An Exploration of Vinamidinium Salts for Frame‐Shifted Synthesis

Israel Journal of Chemistry, Volume 66, Issue 4, July 2026.
Oligoheterocycles are widely used in drug discovery and materials science, where they serve as attractive alternatives to peptide fragments. There is strong interest in understanding the structural correspondence between heterocycles and amino acid motifs to recapitulate key binding elements while improving metabolic stability.
Morgan J. Cordell, Chelsey Brien, Thomas Sidarta Setio, Andrei K. Yudin   +3 more
wiley   +1 more source

A quantitative approach to nucleophilic organocatalysis

Beilstein Journal of Organic Chemistry, 2012
The key steps in most organocatalytic cyclizations are the reactions of electrophiles with nucleophiles. Their rates can be calculated by the linear free-energy relationship log k(20 °C) = sN(E + N), where electrophiles are characterized by one parameter
Herbert Mayr, Sami Lakhdar, Biplab Maji, Armin R. Ofial   +3 more
doaj   +1 more source

Asymmetric Michael Addition of Cyanide to α,β‐Unsaturated Aldehydes Catalyzed by Diarylmethyl‐Substituted Diphenylprolinol Silyl Ethers: Thermodynamically Controlled Product Formation under Kinetic Enantioselective Catalysis

Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.
Asymmetric Michael addition of cyanide to α,β‐unsaturated aldehydes catalyzed by diarylmethyl‐substituted diphenylprolinol silyl ethers:Thermodynamically controlled product formation under kinetic enantioselective catalysis. Diphenylprolinol silyl ether catalyzed asymmetric Michael/1,2‐addition reaction of cyanide to α,β‐unsaturated aldehydes at high ...
Konstantinos Daskalakis, Naoki Mori, Satrajit Indu, Riku Fukami, Yujiro Hayashi   +4 more
wiley   +1 more source