Results 101 to 110 of about 10,956 (235)
Palladium and Organocatalysis: An Excellent Recipe for Asymmetric Synthesis
Molecules, 2013 The dual activation of simple substrates by the combination of organocatalysis and palladium catalysis has been successfully applied in a variety of different asymmetric transformations.
Isidro M. Pastor +3 more
doaj +1 more source
Mechanistic Insights in the Mode of Action of Bifunctional Pyrrolidine-Squaramide-derived Organocatalysts [PDF]
, 2016 The modes of catalytic action of three squaramide-derived bifunctional organocatalysts have been investigated using DFT methods. The [5+2] cycloaddition between oxidopyrilium ylides and enals has been used as model reaction.
Carrillo Fernández, María Luisa +6 more
core +2 more sources
ChemBioChem, EarlyView.Crotonaldehyde‐derived DNA lesions are reported in patients after ethanol exposure, which implies that crotonaldehyde is produced after ethanol ingestion. Here, we show that proline amide, which mimics N‐terminal proline residues on human proteins, can catalyze crotonaldehyde formation from the ethanol metabolite acetaldehyde under physiologically ...
Liam A. Thomas +5 more
wiley +1 more source
Chemical Switching: A Concept Inspired by Strategies from Biocatalysis and Organocatalysis
ChemBioChem, EarlyView.Chemical Switching is introduced as a novel technology that exploits the promiscuity of enzymatic transformations by applying small molecule organocatalytic switches (ORCAs) or gain‐of‐function protein variants. The modulation of underlying chemical principles thereby amplifies low‐rate or installs otherwise absent enzymatic activities to dominate ...
Torkild Visnes +5 more
wiley +1 more source
Water-compatible hydrogen-bond activation: A scalable and organocatalytic model for the stereoselective multicomponent aza-henry reaction [PDF]
, 2016 A study was conducted to demonstrate that H-bond based asymmetric organocatalysis can be performed under the so-called in the presence of water conditions.
Armas, Pedro de +2 more
core +1 more source
Catalysis in Chemical Modification of Proteins
ChemCatChem, EarlyView.Catalytic principles of synthetic organic chemistry have been increasingly applied to chemical modification of proteins during the recent years. This review article describes how seven types of catalytic systems —electrocatalysis, photocatalysis, metal catalysis, acid catalysis, organocatalysis, supramolecular catalysis, and heterogeneous catalysis ...
Seiya Ishizawa +4 more
wiley +1 more source
ChemCatChem, EarlyView.The efficient and robust enantioselective organocatalytic methodology was developed for the conjugate addition of isoxazol‐5(4H)‐ones to aurone‐derived azadienes. This approach provided products featuring benzofuran and isoxazole rings with high yields and enantioselectivities.
Ricardo Torán +4 more
wiley +1 more source
A quantitative approach to nucleophilic organocatalysis
Beilstein Journal of Organic Chemistry, 2012 The key steps in most organocatalytic cyclizations are the reactions of electrophiles with nucleophiles. Their rates can be calculated by the linear free-energy relationship log k(20 °C) = sN(E + N), where electrophiles are characterized by one parameter
Herbert Mayr +3 more
doaj +1 more source
A One-Pot Tandem Strategy in Catalytic Asymmetric Vinylogous Aldol Reaction of Homoallylic Alcohols
Molecules, 2016 Reported is a rationally-designed one-pot sequential strategy that allows homoallylic alcohols to be employed in a catalytic, asymmetric, direct vinylogous aldol reaction with a series of activated acyclic ketones, including trifluoromethyl ketones, γ ...
Xufeng Hou +3 more
doaj +1 more source
Poly(ethylene glycol)-supported ααα-trifluoroacetophenone in dioxirane mediated alkene epoxidation reactions [PDF]
, 2004 Poly(ethylene glycol) (PEG) was used for the immobilization of ααα-trifluoroacetophenone and the utility of this supported ketone has been examined in dioxirane mediated epoxidation of alkenes.
Kan, JTW, Toy, P
core +1 more source