Design and Synthesis of Helical N-Terminal l-Prolyl Oligopeptides Possessing Hydrocarbon Stapling
Molecules, 2020 We designed and synthesized helical short oligopeptides with an l-proline on the N-terminus and hydrocarbon stapling on the side chain. Side-chain stapling is a frequently used method for the development of biologically active peptides.
Atsushi Ueda +4 more
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Thiosemicarbazone organocatalysis:Tetrahydropyranylation and 2-deoxygalactosylation reactions and kinetics-based mechanistic investigation [PDF]
, 2017 Thiosemicarbazones are introduced as a new class of highly tunable and efficient organocatalysts. We showcase this by studies of the tetrahydropyranylation reaction, where insights to the mechanism was achieved by a double Hammett analysis of both the ...
Akselsen, Olivia M. +4 more
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Recent advances in synthesizing and utilizing nitrogen-containing heterocycles
Frontiers in Chemistry, 2023 The use of organocatalysts and a pot economy has strengthened recent organic syntheses. Synthetic methodologies may be applicable in laboratory preparation or in the industrial production of valuable organic compounds. In most cases, synthetic challenges
Hyun-Joon Ha
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Solvent-dependent enantioswitching in the Michael addition of α,α-disubstituted aldehydes to maleimides organocatalyzed by mono-N-Boc-protected cyclohexa-1,2-diamines [PDF]
, 2014 Enantiomerically pure mono-N-Boc-protected trans-cyclohexa-1,2-diamines are used as organocatalysts for the enantioselective conjugate addition of α,α-disubstituted aldehydes to maleimides.
Chinchilla, Rafael +1 more
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D-ribose based organo catalyst for the sustainable synthesis of bioactive biscoumarins
Results in ChemistryHerein, the reported work includes the design and synthesis of D-ribose containing DABCO (1,4-diazabicyclo[2.2.2]octane) sugar ionic liquid (DD-RSIL) via three steps and employed an organocatalyst for the synthesis of methylene or methine substituted ...
Pavani Yasam, Rajagopal Desikan
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The effects of interactions between proline and carbon nanostructures on organocatalysis in the Hajos-Parrish-Eder-Sauer-Wiechert reaction [PDF]
, 2014 The non-covalent interactions of S-(-)-proline with the surfaces of carbon nanostructures (fullerene, nanotubes and graphite) change the nucleophilic-electrophilic and acid-base properties of the amino acid, thus tuning its activity and selectivity in ...
A. N. Khlobystov +44 more
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Beilstein Journal of Organic Chemistry, 2019 A convenient protocol was developed for the synthesis of 2,3-unsaturated C-, O-, N- and S-linked glycosides (enosides) using 20 mol % perflurophenylboronic acid catalyst via Ferrier rearrangement.
Madhu Babu Tatina +3 more
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Enantioselective Synthesis of Succinimides by Michael Addition of Aldehydes to Maleimides Organocatalyzed by Chiral Primary Amine-Guanidines [PDF]
, 2013 The monoguanylation of (1S,2S)- and (1R,2R)-cyclohexane-1,2-diamine affords chiral primary amine-guanidines that are used as chiral organocatalysts in the enantioselective Michael addition of aldehydes, particularly α,α-disubstituted aldehydes, to ...
Chinchilla, Rafael +3 more
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Molecules, 2016 Cyanation reactions of carbonyl compounds with methyl cyanoformate or acetyl cyanide catalyzed by 5 mol % of 1,5,7-triazabicyclo[4,4,0]dec-5-ene (TBD) were examined.
Satoru Matsukawa +2 more
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Stereodivergent, Diels-Alder-initiated organocascades employing α,β-unsaturated acylammonium salts: scope, mechanism, and application. [PDF]
, 2017 Chiral α,β-unsaturated acylammonium salts are novel dienophiles enabling enantioselective Diels-Alder-lactonization (DAL) organocascades leading to cis- and trans-fused, bicyclic γ- and δ-lactones from readily prepared dienes, commodity acid chlorides ...
Abbasov, Mikail E +3 more
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