Results 61 to 70 of about 136,612 (370)

Hepatocytes differentiate into intestinal epithelial cells through a hybrid epithelial/mesenchymal cell state in culture

Nature Communications
Hepatocytes play important roles in the liver, but in culture, they immediately lose function and dedifferentiate into progenitor-like cells. Although this unique feature is well-known, the dynamics and mechanisms of hepatocyte dedifferentiation and the ...
Shizuka Miura, Kenichi Horisawa, Tokuko Iwamori, Satoshi Tsujino, Kazuya Inoue, Satsuki Karasawa, Junpei Yamamoto, Yasuyuki Ohkawa, Sayaka Sekiya, Atsushi Suzuki   +9 more
doaj   +1 more source

Cyborg Organoids: Implantation of Nanoelectronics via Organogenesis for Tissue-Wide Electrophysiology

bioRxiv, 2019
Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies, yet issues arise from invasive, localized implantation of electronics that destructs the well-connected cellular networks ...
Qiang Li, Kewang Nan, P. Le Floch, Zuwan Lin, Hao Sheng, Thomas S Blum, Jia Liu   +6 more
semanticscholar   +1 more source

Simulating Organogenesis in COMSOL: Comparison Of Methods For Simulating Branching Morphogenesis

, 2017
During organogenesis tissue grows and deforms. The growth processes are controlled by diffusible proteins, so-called morphogens. Many different patterning mechanisms have been proposed.
Aland, Sebastian, Iber, Dagmar, Peters, Michael, Wittwer, Lucas D.   +3 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Thrombospondin 1 and 2 regulate mesenchymal progenitor cell fate and matrix organization

Bone Research
Thrombospondin 1 and 2 (TSP1 and TSP2) are critical regulators of extracellular matrix (ECM) interactions, influencing cell differentiation and tissue repair.
Madysen K. Hunter, Sneha Korlakunta, Neda Vishlaghi, Monisha Mittal, Kyle Cragg, Conan Juan, Chase A. Pagani, Yuxiao Sun, Lindsey Lammlin, Karen Kessell, Dylan Feist, Ji Hae Choi, Meng-Lun Hsieh, Jahnu Saikia, Craig L. Duvall, Heeseog Kang, Andrea I. Alford, Kurt D. Hankenson, Robert J. Tower, Tristan Maerz, Benjamin Levi   +20 more
doaj   +1 more source

Regeneration of begonia plantlets by direct organogenesis [PDF]

, 2009
The economic importance of ornamentals worldwide suggests a bright future for ornamental breeding. Rapid progress in plant molecular biology has great potentials to contribute to the breeding of novel ornamental plants utilizing recombinant DNA ...
Curuk, P., Eldoğan, S., Gencel, G., Kocaman, E., Mendi, Yalçın Y., Unek, C., Çetiner, Selim   +6 more
core  

Lineage dynamics of murine pancreatic development at single-cell resolution. [PDF]

, 2018
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time.
Byrnes, Lauren E, Gilchrist, Caroline L, Knox, Sarah M, Meyer, Nathaniel P, Sneddon, Julie B, Subramaniam, Meena, Tward, Aaron D, Wong, Daniel M, Ye, Chun J   +8 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Cell polarity and patterning by PIN trafficking through early endosomal compartments in Arabidopsis thaliana [PDF]

, 2013
PIN-FORMED (PIN) proteins localize asymmetrically at the plasma membrane and mediate intercellular polar transport of the plant hormone auxin that is crucial for a multitude of developmental processes in plants.
De Rycke, Riet, Feraru, Ioan Mugurel, Friml, Jiri, Kakimoto, Tatsuo, Kitakura, Saeko, Rakusova, Hana, Robert, Stephanie, Tanaka, Hirokazu, Uemura, Tomohiro   +8 more
core   +9 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source