Results 61 to 70 of about 72,062 (325)

Advances in Microfluidic Cochlea‐On‐A‐Chip

Advanced Science, EarlyView.
This review systematically examines diverse cell sources for inner ear organoids and outlines stepwise induction protocols. Furthermore, it discusses current applications and prospective developments of cochlea‐on‐a‐chip technologies in areas such as deafness modeling, mechanistic studies, and drug evaluation, with particular focus on gene‐therapy drug
Tian Shen, Shanying Han, Weiwei He, Wen Yang, Xinghua Tang, Xiaolong Zhao, Xinghong Liu, Zhenhua Shao, Lin Cheng, Yu Zhao, Jiangang Fan   +10 more
wiley   +1 more source

Modeling mammary organogenesis from biological first principles: Cells and their physical constraints [PDF]

Progress in Biophysics and Molecular Biology 122(1), 2016, P. 58-69, 2017
In multicellular organisms, relations among parts and between parts and the whole are contextual and interdependent. These organisms and their cells are ontogenetically linked: an organism starts as a cell that divides producing non-identical cells, which organize in tri-dimensional patterns. These association patterns and cells types change as tissues
arxiv   +1 more source

Lymphoid organogenesis in brief [PDF]

European Journal of Immunology, 2007
The recognition that lymphocytes existed in different varieties and that lymphoid organs were important for their differentiation greatly influenced immunological research. The growing awareness that started in the mid-fifties of the previous century has shifted the emphasis of immunology from a molecular, mostly serological science to the cell ...
Vondenhoff, Mark F R, Kraal, Georg, Mebius, Reina E   +2 more
openaire   +4 more sources

Single-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis

Genome Biology, 2018
Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this process at single-cell resolution remain elusive.
Ji Dong, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Y. Mao, Boqiang Hu, Hongshan Guo, Lu Wen, Fuchou Tang   +8 more
semanticscholar   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

Scientific Reports, 2023
Direct reprogramming, inducing the conversion of one type of somatic cell into another by the forced expression of defined transcription factors, is a technology with anticipated medical applications.
Kenichi Horisawa, Shizuka Miura, Hiromitsu Araki, Fumihito Miura, Takashi Ito, Atsushi Suzuki   +5 more
doaj   +1 more source

Tissue flow induces cell shape changes during organogenesis [PDF]

Biophysical Journal Dec 2018, 115(11):2259-2270, 2018
In embryonic development, programmed cell shape changes are essential for building functional organs, but in many cases the mechanisms that precisely regulate these changes remain unknown. We propose that fluid-like drag forces generated by the motion of an organ through surrounding tissue could generate changes to its structure that are important for ...
arxiv   +1 more source

De novo shoot organogenesis during plant regeneration.

Journal of Experimental Botany, 2019
Plants exhibit remarkable regeneration capacity, ensuring developmental plasticity. In vitro tissue culture techniques are based on the plant regeneration ability and facilitate production of new organs and even whole plant from explants.
Jinwoo Shin, S. Bae, P. Seo
semanticscholar   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source