The regenerative capacity of hepatocyte organoids following long-term cryopreservation in Republic of Korea [PDF]
OrganoidBackground Hepatocyte organoids (HOs) are more functionally versatile than bile duct epithelial cell organoids, but have a shorter lifespan. This limitation has been improved by optimizing culture methods, but could remain a barrier to their wider ...
Sun A Ock +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This research introduces a cold plasma‐based platform for treating breast cancer bone metastases. Using a novel bioprinted 3D tumor‐stroma model, it highlights the selective antitumor effects of plasma‐generated reactive species. The platform aims to advance non‐invasive therapeutic strategies, offering potential clinical applications in controlling ...
Laura M. Bouret +4 more
wiley +1 more source
In vitro study: generation of a non-invasive patient-derived neurodegenerative model for spinocerebellar ataxia 6 [PDF]
OrganoidBackground Spinocerebellar ataxia (SCA) is a rare neurodegenerative disorder defined by genetic mutations that cause gait disturbances and impaired motor coordination.
Youngsun Lee, Mi-Ok Lee
doaj +1 more source
A population of c-Kitlow(CD45/TER119)– hepatic cell progenitors of 11-day postcoitus mouse embryo liver reconstitutes cell-depleted liver organoids [PDF]
, 2003 Susana Minguet +8 more
openalex +2 more sources
Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
Advanced Healthcare Materials, EarlyView.This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han +7 more
wiley +1 more source
Targeting the tumor microenvironment in colorectal peritoneal metastases
, 2020 Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim +4 more
core +1 more source
Advanced Healthcare Materials, EarlyView.An advanced on‐chip cortical network platform merges human stem cell‐derived neurons with microfabricated devices, enabling precise large‐format circuit design, optogenetic control, and molecular dissection of synaptic formation. This innovative system offers a powerful new tool to explore and model brain connectivity, disease mechanisms, can serve as ...
Pacharaporn Suklai +9 more
wiley +1 more source
Cell Calcification Models and Their Implications for Medicine and Biomaterial Research
Advanced Healthcare Materials, EarlyView.Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter +5 more
wiley +1 more source
Preservation of Functioning Human Thyroid "Organoids" in the scid Mouse. IV. In Vivo Selection of an Intrathyroidal T Cell Receptor Repertoire [PDF]
, 1997 Ana Fernandez Martin
openalex +1 more source
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. [PDF]
, 2020 Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this study, we report a axis by which inflammatory cytokines, such as IL-17, drive cellular copper ...
Bao, Shideng +16 more
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