Results 171 to 180 of about 58,747 (290)

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Organoids [PDF]

Nature Methods, 2018
openaire   +1 more source

Brain‐inspired intelligence‐driven scientific research

Brain-X
Long Bai, Jiacan Su
doaj   +1 more source

Development and characterization of functional sheep endometrial luminal epithelial organoids. [PDF]

Vet Res
Guo J, Huang X, Xia R, Gao Q, Yang H, Wang L, Mai Q, Deng M, Zhang G, Zhang Y, Wang F.   +10 more
europepmc   +1 more source

Inhibition of Focal Adhesion Restricts Chemoresistance in Pancreatic Cancer by Targeting SLC7A11 Mediated Ferroptosis

Advanced Science, EarlyView.
FAK signaling drives chemoresistance and tumor evolution in pancreatic ductal adenocarcinoma. The FAK inhibitor IN10018 restores gemcitabine sensitivity by inducing SLC7A11‐mediated ferroptosis through the PI3K‐Akt pathway and remodeling the tumor microenvironment, reducing mesenchymal components while enhancing CD8+ T‐cell infiltration in preclinical ...
Yingjin Wang, Hui Yang, Baoyuan Zhang, Yongsu Ma, Kuangen Zhang, Peng Wang, Jiapeng Yang, Zaiqi Wang, Rong Liu, Xiaodong Tian, Ning Zhang, Yinmo Yang   +11 more
wiley   +1 more source

Matrix type influences embedded patient-derived osteosarcoma organoid invasion and response to treatment. [PDF]

Front Pharmacol
Hipwood L, Vargas Reyes DM, Thompson EW, Rowell PD, Lowe M, Nicholls W, Bhatia S, Hutmacher DW, Meinert C, McGovern JA.   +9 more
europepmc   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

An integrated patient-derived colon organoids platform as a functional model for nutraceutical and stress response. [PDF]

iScience
Costantino A, Bonacci PG, Zerbo G, Luca T, Popov O, Terrana M, Sargenti A, Cristaldi DA, Bonaccorso C, Fortuna CG, Puleo S, Coco O, Magro G, Lanzanò L, Castorina S, Musso N, Gulisano M.   +16 more
europepmc   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Building global research equity through lung organoids: a prerequisite for the next respiratory pandemic

Frontiers in Medicine
Muhammad Kamal Hossain, Muhammad Kamal Hossain, Muhammad Kamal Hossain, Hyung-Ryong Kim, Hyung-Ryong Kim   +4 more
doaj   +1 more source