Results 181 to 190 of about 74,769 (302)

Stem Cell-Derived Organoids for Cancer Therapy: Precision Medicine and Drug Selection. [PDF]

Int J Mol Sci
Azim MMN, Bhajan SK, Park JH, Abass KS, Rahman A, Choi M, Choi J, Park S, Kim HJ, Akter S, Rani A, Kim B.   +11 more
europepmc   +1 more source

Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

Advanced Science, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) exhibits addiction to chronic endoplasmic reticulum (ER) stress, which sustains an aggressive metastatic phenotype through activation of the unfolded protein response (UPR). Here, we identify a previously unrecognized “ER‐stress addiction” axis in which the Hippo pathway effector TEAD4 directly ...
Yini Shang, Wentao Si, Youxue Zhang, Jialin Liu, Huaixi Zhang, Yafei Li, Hongmeng Su, Wei Jiang, Zhishan Ding, Lihong Wang   +9 more
wiley   +1 more source

Building global research equity through lung organoids: a prerequisite for the next respiratory pandemic

Frontiers in Medicine
Muhammad Kamal Hossain, Muhammad Kamal Hossain, Muhammad Kamal Hossain, Hyung-Ryong Kim, Hyung-Ryong Kim   +4 more
doaj   +1 more source

Incubation of brain organoids with fluorescent carbon nanodots. [PDF]

RSC Adv
Sprengel C, Fischer U, Borkhardt A, Haas R, Heinzel T.   +4 more
europepmc   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Comparative Multiomics Analysis of Cerebral Organoid-Derived Exosomes during Organoid Maturation. [PDF]

Nano Lett
Kim YE, Kim SS, Lee J, Park SB, Jo JH, Cho HJ, Choi KJ, Im J, Seo WR, Park Y, Kim S, Bae MA, Kim KY, Cho SH, Kang D, Koh B.   +15 more
europepmc   +1 more source

Zika virus has oncolytic activity against glioblastoma stem cells [PDF]

, 2017
Diamond, Michael S, et al,, Tycksen, Eric   +2 more
core   +2 more sources

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species. [PDF]

Emerg Microbes Infect
Tarrés-Freixas F, Ceada G, Català-Moll F, Casadellà M, Tolosa-Alarcón S, Franco-Trepat E, Boreika R, Almagro-Delgado V, Carmona N, Estruch J, Fernández-Bellon H, Fuentes-Moyano L, Molina-López R, Navarro N, Parera M, Pérez-Simó M, Repullés J, Roca N, Torné O, Velarde R, Valencia A, Paredes R, Izquierdo-Useros N, Romero-Durana M, Kochanowski K, Vergara-Alert J.   +25 more
europepmc   +1 more source

Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment

, 2020
Berger, H., Braicu, E., Chekerov, R., Darb-Esfahani, S., Hoffmann, K., Kessler, M., Kulbe, H., Mangler, M., Meyer, T., Mollenkopf, H., Sehouli, J., Taube, E., Thillainadarasan, S., Zemojtel, T.   +13 more
core   +1 more source