Results 251 to 260 of about 90,274 (350)

AI and organoid platforms for brain-targeted theranostics. [PDF]

Theranostics
Ye R, Zhang Y, Xu W, Lai L, Zhang Z, Chen Y, Qin S.   +6 more
europepmc   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

A convective transport-enhanced multi-organoid device for therapeutic modeling of the liver-pancreas axis in obesity. [PDF]

Theranostics
Kim J, Bae J, Cui B, Cho SW, Yang K.
europepmc   +1 more source

Correlation of the treatment sensitivity of patient-derived organoids with treatment outcomes in patients with head and neck cancer (SOTO): protocol for a prospective observational study [PDF]

I. Vasiliadou, C. Cattaneo, Phoebe Yuen Ka Chan, Rhonda Henley‐Smith, Harry Gregson-Williams, Lisette Collins, Gabriella Wojewodka, Teresa Guerrero Urbano, Jean‐Pierre Jeannon, Steve Connor, Jessica L. Davis, Anna Pastò, Rami Mustapha, Tony Ng, Anthony Kong   +14 more
openalex   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Immune and Immune-Integrated Organoids as NextGeneration Platforms for Disease Modeling. [PDF]

MedComm (2020)
Rashidan K, Ayadilord M, Hazrati A, Nazerian A, Shafiee A, Hashemi SM.   +5 more
europepmc   +1 more source

Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a PAR1- and PAR4-dependent mechanism

, 2018
Nathalie Vergnolle, Morgane Sébert, Audrey Ferrand, Alexandre Denadai, Claire Racaud‐Sultan, Sophie Chabot, Philippe Lluel, Laurent Alric, Delphine Bonnet   +8 more
openalex   +2 more sources

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Development of synovial sarcoma organoids exhibiting ferroptosis resistance despite low malic enzyme 1 expression. [PDF]

Sci Rep
Wakamatsu T, Yamada Y, Yoshida K, Matsuoka Y, Sasagawa S, Nagamine N, Shizuma K, Suzuki R, Tamiya H, Imura Y, Nakai S, Okada S, Yagi T, Yoshida KI, Kakunaga S, Yui Y, Takenaka S.   +16 more
europepmc   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source