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Developmental Cell
Organoids, 3D in vitro structures derived from embryonic or adult stem cells, offer powerful models for studying tissue patterning, development, morphogenesis, organ physiology, and disease. These systems replicate biological processes, such as cell differentiation, symmetry breaking, and tissue organization, while revealing species-specific ...
Vanessa, Weichselberger +5 more
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Organoids, 3D in vitro structures derived from embryonic or adult stem cells, offer powerful models for studying tissue patterning, development, morphogenesis, organ physiology, and disease. These systems replicate biological processes, such as cell differentiation, symmetry breaking, and tissue organization, while revealing species-specific ...
Vanessa, Weichselberger +5 more
openaire +2 more sources
Nature Reviews Cancer, 2019
Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.
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Neal et al. have successfully established patient-derived organoids of tumour epithelia retaining native immune cells, thereby recapitulating tumour microenvironment diversity and enabling immuno-oncology studies.
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Science, 2017
Hans Clevers pioneered lab-built mini-organs that can serve as models of ...
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Hans Clevers pioneered lab-built mini-organs that can serve as models of ...
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Organoids in Tissue Transplantation
2021Improvements in stem cell-based research and genetic modification tools enable stem cell-based tissue regeneration applications in clinical therapies. Although inadequate cell numbers in culture, invasive isolation procedures, and poor survival rates after transplantation remain as major challenges, cell-based therapies are useful tools for tissue ...
Derya, Sağraç +5 more
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Advances in Organoid Technology: A Focus on Corneal Limbal Organoids
Stem Cell Reviews and ReportsOrganoid technology provides a versatile platform for simulating organogenesis, investigating disease pathogenesis, and exploring therapeutic interventions. Among various types of organoids that have been developed, corneal limbal organoids, the three-dimensional miniaturized corneas which are derived from either pluripotent stem cells or limbal ...
Chuwei Lu, Qihua Le
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En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Cell, 2022Kentaro Iwasawa +2 more
exaly
An in vivo neuroimmune organoid model to study human microglia phenotypes
Cell, 2023Fred H Gage
exaly
Organoids for Genotoxicity Assessment
Organoid cultures mimic the composition, structure, and function of the organ they derive from to a certain extent, providing more physiologically and biologically relevant results to humans than the currently used monolayer cell cultures and animal models.Angela L, Caipa Garcia +1 more
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