Results 281 to 290 of about 114,312 (393)

Reproducibility of PD patient-specific midbrain organoid data for <i>in vitro</i> disease modeling. [PDF]

iScience
Zuccoli E, Al Sawaf H, Tuzza M, Nickels SL, Zagare A, Schwamborn JC.   +5 more
europepmc   +1 more source

MP84-01 IN VITRO CULTURE OF PROSTATE CANCER XENOGRAFTS USING ORGANOID TECHNOLOGY [PDF]

, 2016
Cheryl Nicholson, Elizabeth D. Williams, Ian Vela   +2 more
openalex   +1 more source

Optimized Monothiol Thioredoxin Derivative (ORP100S) Protects In Vitro and In Vivo from Radiation and Chemotoxicity Without Promoting Tumor Proliferation

Advanced Science, EarlyView.
Native thioredoxin‐1 (TRX) stimulates proliferation and rescues stem cells and cancer cells from multiple stressors by suppressing p53 and inhibiting ferroptosis via GPX4/SLC7A11 upregulation mediated by enhanced KLF4 expression and p53 promoter binding.
Jian Wu, Xiaobei Wang, Parker Mathews, Shaima Jabbar, Min Zhang, Haim Moskowitz, Wei Duan, David P. Nichols, George William Schaaf, John D. Olson, Andrew N. Macintyre, J. Daniel Bourland, Ivan Spasojevic, Jen‐Tsan Ashley Chi, Joel Ross, Nelson Chao, J. Mark Cline, Peter B. Heifetz, Yubin Kang   +18 more
wiley   +1 more source

Head and neck cancer organoids: a panoramic perspective from basic construction to clinical translation. [PDF]

Stem Cell Res Ther
Meng R, Yu L, Li X, Ning N, Hao H, Zhang X, Kong J, Song W, Li X.   +8 more
europepmc   +1 more source

Snord15b Maintains Stemness of Intestinal Stem Cells via Enhancement of Alternative Splicing of Btrc Short Isoform for Suppression of β‐Catenin Ubiquitination

Advanced Science, EarlyView.
In intestinal stem cells (ISCs), Snord15b associates with Ilf2 to recruit splicing factors for alternative splicing of Btrc mRNA, leading to the generation of short Btrc. This short Btrc fails to form a functional E3 ubiquitin ligase complex for β‐catenin ubiquitination and degradation.
Yuwei Xu, Peikang Zhang, Zhen Xiong, Yufei Lan, Hui Guo, Runyuan Wu, Cunzhen Li, Hongzhe Fan, Ying Du, Xiaoxiao Zhu, Dongdong Fan, Zhonglong Wang, Yong Tian, Zusen Fan   +13 more
wiley   +1 more source

Regulating closure of the neural tube in humans. [PDF]

Elife
Qarawani L, Hanna JH.
europepmc   +1 more source

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

, 2016
Carla S. Veríssimo, René Overmeer, Bas Ponsioen, Jarno Drost, Sander Mertens, Ingrid Verlaan-Klink, Bastiaan van Gerwen, Marieke van der Ven, Marianne D. van de Wetering, David A. Egan, René Bernards, Hans Clevers, Johannes L. Bos, Hugo J.G. Snippert   +13 more
openalex   +1 more source

Engineering human intestinal organoids with a functional ENS [PDF]

, 2016
Katrina Ray
openalex   +1 more source

Decoding Dental Stem Cell Aging: Mechanisms, Therapeutic Strategies, and Beyond

Advanced Science, EarlyView.
Dental stem cell (DSC) aging involves genomic instability, mitochondrial dysfunction, telomere attrition, and epigenetic alterations, leading to impaired proliferation, reduced differentiation potential, and pro‐inflammatory secretory activity. These processes drive cellular senescence and compromise regenerative and immunomodulatory functions, thereby
Xinyuan Zhao, Yunfan Lin, Pei Lin, Ye Lu, Jiarong Zheng, Xu Chen, Zihao Zhou, Li Cui   +7 more
wiley   +1 more source

Matrix directs trophoblast differentiation in a bioprinted organoid model of early placental development. [PDF]

Nat Commun
Richards C, Chen H, O'Rourke M, Bannister A, Owen G, Volkerling A, Ghosh A, Gorrie CA, Gallego-Ortega D, Bottomley AL, Padula MP, McGrath KC, Cole L, Hansbro PM, McClements L.   +14 more
europepmc   +1 more source