Results 281 to 290 of about 90,274 (350)

Multi-Region Brain Organoid –Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components

Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, Jinghui Guo, Kai Cheng, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E. Badr, Annie Kathuria   +9 more
openalex   +1 more source

Targeting WEE1 in ARID1A/TP53 Concurrent Mutant Colorectal Cancer by Exploiting R‐Loop Accumulation and DNA Repair Deficiencies

Advanced Science, EarlyView.
ARID1A, a SWI/SNF complex component, is frequently mutated in colorectal cancer (CRC). CRC with ARID1A/TP53 concurrent mutations shows marked sensitivity to WEE1 inhibition. ARID1A loss induces R‐loop‐mediated replication stress, impairs ATF3 transcription, and amplifies WEE1i‐induced DNA damage, suggesting a promising therapeutic vulnerability ...
Chi Zhang, Yanjing Zhu, Luoyan Ai, Jingyuan Wang, Shan Yu, Yichen Wang, Xiaojing Xu, Mengling Liu, Yiyi Yu, Mengxuan Zhu, Yutong Liu, Zhenghang Xu, Haojie Zhou, Huishan Li, Qihong Huang, Qing Liu, Ke Peng, Tianshu Liu   +17 more
wiley   +1 more source

Chondrosarcoma organoids reveal SHH pathway activation driven by PTCH1 and BCOR alterations. [PDF]

Sci Rep
Takami H, Yoshida K, Matsuoka Y, Sasagawa S, Nagamine N, Kukita Y, Kiyotani K, Yoshimura Y, Suzuki R, Tamiya H, Kakunaga S, Yagi T, Nakai S, Imura Y, Okada S, Yoshida KI, Takenaka S, Wakamatsu T.   +17 more
europepmc   +1 more source

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Personalized prediction of chemotherapy efficacy in osteosarcoma through patient-derived organoids: correlation with survival and tumor proliferation potential. [PDF]

J Exp Clin Cancer Res
Nie JH, Wan CY, Li H, Zhou JL, Zhong GQ, Yang T, Yao MY, Huang WH, Zhang C, Li S, Liu J, Li W, Zhang Y.   +12 more
europepmc   +1 more source

Dynamic hydrogel mechanics in organoid engineering: From matrix design to translational paradigms

Chenyue Zhang, Yue Shen, Ming-Yang Huang, Guoqing Wang, Qing Miao, Heping Shi, Robert X. Gao, Kun Wang, Ming Luo   +8 more
openalex   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Self-Organizing Ovarian Somatic Organoids Preserve Cellular Heterogeneity and Reveal Cellular Contributions to Ovarian Aging. [PDF]

Aging Cell
Dipali SS, Converse A, Gowett MQ, Kamat P, Zaniker EJ, Fennell A, Chou T, Pritchard MT, Zelinski M, Phillip JM, Duncan FE.   +10 more
europepmc   +1 more source

Efferocytosis‐Driven Polyamine Metabolism in Macrophages Enhances Cancer Stem Cell Enrichment after Chemotherapy in Ovarian Cancer

Advanced Science, EarlyView.
Chemotherapy‐induced efferocytosis drives ovarian cancer stem cell enrichment. By engulfing apoptotic cancer cells, macrophages upregulate ODC1 and produce putrescine, which elevates osteopontin (OPN) expression. Secreted OPN then activates the CD44 receptor on cancer cells, promoting stemness and chemoresistance.
Wenhan Li, Feiquan Ying, Xinkai Pang, Qiulei Wu, Guoqing Li, Lin Huang, Jiayu Xin, Xiaoli Liu, Pan Liu, Xiaohan Xu, Shuran Tan, Yumei Gao, Tong Liu, Si Sun, Xiaoman Wang, Yiping Wen, Liqiong Cai, Shi Du, Yuan Zhang, Jing Cai   +19 more
wiley   +1 more source

Modeling Drug and Radiation Resistance with Patient-Derived Organoids: Recent Progress, Unmet Needs, and Future Directions for Lung Cancer. [PDF]

Cells
Lee D, Kim Y, Kang DH, Chung C.
europepmc   +1 more source