Results 71 to 80 of about 114,312 (393)
Engineering Organoid Vascularization [PDF]
Frontiers in Bioengineering and Biotechnology, 2019 The development of increasingly biomimetic human tissue analogs has been a long-standing goal in two important biomedical applications: drug discovery and regenerative medicine. In seeking to understand the safety and effectiveness of newly developed pharmacological therapies and replacement tissues for severely injured non-regenerating tissues and ...
Grebenyuk, Sergei, Ranga, Adrian
openaire +3 more sources
Metabolism of parathyroid organoids
Frontiers in Endocrinology, 2023 IntroductionWe successfully developed a broad spectrum of patient-derived endocrine organoids (PDO) from benign and malignant neoplasms of thyroid, parathyroid, and adrenal glands. In this study, we employed functionally intact parathyroid PDOs from benign parathyroid tissues to study primary hyperparathyroidism (PHPT), a common endocrine metabolic ...
Konjeti R. Sekhar +7 more
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Journal of experimental & clinical cancer research : CR, 2022 Background Cancer-associated fibroblasts (CAFs) are considered to play a fundamental role in pancreatic ductal adenocarcinoma (PDAC) progression and chemoresistance.
Sebastian Schuth +9 more
semanticscholar +1 more source
Basement membrane-rich Organoids with functional human blood vessels are permissive niches for human breast cancer metastasis [PDF]
, 2013 Metastasic breast cancer is the leading cause of death by malignancy in women worldwide. Tumor metastasis is a multistep process encompassing local invasion of cancer cells at primary tumor site, intravasation into the blood vessel, survival in systemic ...
Alonso-Camino, Vanesa +12 more
core +4 more sources
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]
, 2018 Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita +6 more
core +3 more sources
Organoid assessment technologies
Clinical and Translational Medicine, 2023 AbstractDespite enormous advances in the generation of organoids, robust and stable protocols of organoids are still a major challenge to researchers. Research for assessing structures of organoids and the evaluations of their functions on in vitro or in vivo is often limited by precision strategies. A growing interest in assessing organoids has arisen,
Yuyuan Gu +5 more
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Polarised epithelial monolayers of the gastric mucosa reveal insights into mucosal homeostasis and defence against infection [PDF]
, 2018 Objective Helicobacter pylori causes life-long colonisation of the gastric mucosa, leading to chronic inflammation with increased risk of gastric cancer.
Berger, H. +10 more
core +3 more sources
Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]
, 2020 Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony +3 more
core +1 more source
Natural Hydrogels Support Kidney Organoid Generation and Promote In Vitro Angiogenesis
Advances in MaterialsTo date, strategies aiming to modulate cell to extracellular matrix (ECM) interactions during organoid derivation remain largely unexplored. Here renal decellularized ECM (dECM) hydrogels are fabricated from porcine and human renal cortex as biomaterials
E. Garreta +18 more
semanticscholar +1 more source
Challenges of Organoid Research.
Annual Review of Neuroscience, 2022 Organoids are 3D cell culture systems derived from human pluripotent stem cells that contain tissue resident cell types and reflect features of early tissue organization. Neural organoids are a particularly innovative scientific advance given the lack of
Madeline G. Andrews, A. Kriegstein
semanticscholar +1 more source