Results 71 to 80 of about 5,723 (210)

Programmable biomaterials for bone regeneration

Materials Today Bio
Programmable biomaterials are distinguished by their ability to adjust properties and functions on demand, in a periodic, reversible, or sequential manner.
Peiran Song, Dongyang Zhou, Fuxiao Wang, Guangfeng Li, Long Bai, Jiacan Su   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Organoide

Medizinrecht, 2020
Organoids are developed from stem cells and serve as three-dimensional model systems for different organs. They have great potential for research and medicine, but also raise philosophical, ethical and legal questions which have rarely been discussed in Germany so far.
openaire   +3 more sources

Advances in biomarkers and diagnostic significance of organ aging

Fundamental Research
A complete understanding of aging is a critical first step in treating age-related diseases and postponing aging dysfunction in the context of an aging global population.
Yulin Chen, Jiadong Li, Xinru Liu, Zhen Geng, Ke Xu, Jiacan Su   +5 more
doaj   +1 more source

Developments in endoderm and pancreatic β-cell differentiation from human pluripotent stem cells [PDF]

Organoid
Human pluripotent stem cells (hPSCs) can differentiate into any cell type in the body, including cells or tissues from ectodermal, mesodermal, or endodermal lineages.
Dong Hyeon Lee, Hwajung Choo, Hyo Yi Choi, Sung Hwan Lee   +3 more
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Advancements in brain organoid models for neurodegenerative disease research [PDF]

Organoid
Neurodegenerative diseases (NDs) such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) are progressive disorders characterized by complex, human-specific pathology that poses challenges to drug discovery efforts. Traditional models, including two-
Soomin Park, Jong-Chan Park
doaj   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

Osteoblast-derived extracellular vesicles exert bone formation effects by WIF1-mediated regulation of mitophagy

Medicine Plus
Background: Osteoporosis arises mainly from an imbalance in bone remodeling, characterized by the impaired ability of osteoblasts (OBs) to form new bone.
Yuyuan Gu, Jing Zhao, Jian Wang, Yingying Jiang, Yingying Jing, Ke Xu, Jiacan Su   +6 more
doaj   +1 more source

A clinician’s perspective: what tumor-organoid researchers ought to know [PDF]

Organoid
Patient-derived tumor organoids (PDTOs) provide powerful platforms for modeling human tumors, offering insights into cancer biology and personalized therapy development.
Jeong Uk Lim
doaj   +1 more source