Results 111 to 120 of about 1,044,908 (274)

Why brain organoids are not conscious yet. [PDF]

Rapid advances in human brain organoid technologies have prompted the question of their consciousness. Although brain organoids resemble many facets of the brain, their shortcomings strongly suggest that they do not fit any of the operational definitions
Kosik, Kenneth
core   +1 more source

Capability Development in the European Medicines Regulatory Network—A European Learning Needs Analysis and Survey Study

Clinical Pharmacology &Therapeutics, EarlyView.
The European Medicines Regulatory Network plays a critical role in safeguarding public health through the assessment and supervision of human medicines. However, rapid scientific and technological advancements have exposed capability deficits across the network, threatening timely and effective regulatory decision‐making.
Naomi Beard, Marko J. Kallio, Luca Kosec, Ulrika Espefält Westin, on behalf of the IncreaseNET consortium   +4 more
wiley   +1 more source

Organoid‐Guided Precision Medicine: From Bench to Bedside

MedComm
Organoid technology, as an emerging field within biotechnology, has demonstrated transformative potential in advancing precision medicine. This review systematically outlines the translational trajectory of organoids from bench to bedside, emphasizing ...
Boqiang Tao, Xiaolan Li, Ming Hao, Tian Tian, Yuyang Li, Xiang Li, Chun Yang, Qirong Li, Qiang Feng, Hengzong Zhou, Yicheng Zhao, Dongxu Wang, Weiwei Liu   +12 more
doaj   +1 more source

Defining the challenges and opportunities for using patient-derived models in prostate cancer research [PDF]

BackgroundThere are relatively few widely used models of prostate cancer compared to other common malignancies. This impedes translational prostate cancer research because the range of models does not reflect the diversity of disease seen in clinical ...
Anselmino, N, Bock, N, Brennen, WN, Butler, LM, Choo, N, Clark, AK, Coleman, IM, Corey, E, Dolgos, R, Ferguson, AM, Goode, DL, Julio, MKD, Karkampouna, S, Lawrence, MG, Le Magnen, C, Navone, NM, Nelson, PS, O'Neill, E, Porter, LH, Ranasinghe, W, Risbridger, GP, Sunada, T, Taylor, RA, van Weerden, WM, Williams, ED   +24 more
core   +1 more source

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, EarlyView.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source

Stem Cells and Organoids: A Paradigm Shift in Preclinical Models Toward Personalized Medicine

Pharmaceuticals
Background/Objectives: Human pluripotent stem cells (hPSCs) and organoid technologies are transforming pharmaceutical research by providing models that more accurately reflect human physiology, genetic variability, and disease mechanisms.
Eleanor Luce, Jean-Charles Duclos-Vallee
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Micro Pattern‐Based 3D Cell Culture Platform: An Overview of Technologies and Applications

Exploration, EarlyView.
Micro patterns are characterized as a coating of specific adhesion matrices on substrates to support cell growth. An overview of micropattern technology to regulate single cell morphology and fates, further focusing on the micro pattern‐based 3D cell culture platform used in the non‐tumor and tumor researches.
Xinglong Zhu, Yi Li, Hulin Long, Yijia Wu, Ningwei Sun, Shun Li, Yiyao Liu, Huiqi Xie, Ji Bao   +8 more
wiley   +1 more source

Immune Organoids: A Review of Their Applications in Cancer and Autoimmune Disease Immunotherapy

Current Issues in Molecular Biology
Immune organoids have emerged as a ground-breaking platform in immunology, offering a physiologically relevant and controllable environment to model human immune responses and evaluate immunotherapeutic strategies.
David B. Olawade, Emmanuel O. Oisakede, Eghosasere Egbon, Saak V. Ovsepian, Stergios Boussios   +4 more
doaj   +1 more source

NASA patent abstracts bibliography: A continuing bibliography. Section 1: Abstracts (supplement 37) [PDF]

s are provided for 76 patents and patent applications entered into the NASA scientific and technical information systems during the period January 1990 through June 1990.

core   +1 more source