Results 141 to 150 of about 1,044,908 (274)

Iteration of Tumor Organoids in Drug Development: Simplification and Integration

Pharmaceuticals
The inherent complexity and heterogeneity of tumors pose substantial challenges for the development of effective oncology therapeutics. Organoids, three-dimensional (3D) in vitro models, have become essential tools for predicting therapeutic responses ...
Rui Zhao, Qiushi Feng, Yangyang Xia, Lingzi Liao, Shang Xie   +4 more
doaj   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

AI, agentic models and lab automation for scientific discovery — the beginning of scAInce

Frontiers in Artificial Intelligence
Until recently, the conversation about generative artificial intelligence in science revolved around the textual prowess of large language models such as GPT-3.5 and the promise that they might one day draft a decent literature review.
Thomas Hartung, Thomas Hartung
doaj   +1 more source

Organoid Intelligence: The Crossroads of Biology and Artificial Intelligence [PDF]

, 2023
Abdullah, Ishan S., Koutroulis, Ioannis, Loganathan, Aditya, Pierce, Ayal Z.   +3 more
core   +1 more source

Deep Learning Integration in Optical Microscopy: Advancements and Applications

Microscopy Research and Technique, EarlyView.
It explores the integration of DL into optical microscopy, focusing on key applications including image classification, segmentation, and computational reconstruction. ABSTRACT Optical microscopy is a cornerstone imaging technique in biomedical research, enabling visualization of subcellular structures beyond the resolution limit of the human eye ...
Pottumarthy Venkata Lahari, Sagnika Dutta, H. Deeksha, Samreen A. Patel, Budheswar Dehury, Nirmal Mazumder   +5 more
wiley   +1 more source

Bridging the gap: how patient-derived lung cancer organoids are transforming personalized medicine

Frontiers in Cell and Developmental Biology
Lung cancer is a major malignancy that poses a significant threat to human health, with its complex pathogenesis and molecular characteristics presenting substantial challenges for treatment.
Chaoxing Liu, Chaoxing Liu, Chaoxing Liu, Chao Shi, Chao Shi, Chao Shi, Siya Wang, Rong Qi, Rong Qi, Rong Qi, Weiguo Gu, Weiguo Gu, Weiguo Gu, Feng Yu, Feng Yu, Guohua Zhang, Feng Qiu, Feng Qiu   +17 more
doaj   +1 more source

Nano Delivery Strategy Opens Effective Avenues for the Treatment of Colorectal Cancer

Medicine Bulletin, EarlyView.
ABSTRACT Colorectal cancer (CRC) presents significant therapeutic challenges because of chemoresistance, systemic toxicity, and the complexity of the tumor microenvironment (TME). Nanodrug delivery systems (NDDS) have emerged as versatile platforms capable of overcoming these limitations by enhancing tumor accumulation, improving pharmacokinetics, and ...
Qiurong Wei, Yunli Xu, Tianjiao Zhang, Shuyu Xu, Haonan Wang, Yuan Wang, Xinxin Xie, Xiaolong Liang   +7 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Human Brain Organoids in the Preclinical Phase of Drug Development for Migraine [PDF]

Developing drugs for brain disorders poses significant hurdles. These challenges stem from the scarcity of optimal models for preclinical drug testing and the often observed lack of translation from preclinical to human clinical trials.
Gazerani, Parisa
core  

iLABMED: A Translational Medical Journal Embracing a New Era

iLABMED, EarlyView.
Tetsuya Asakawa, Yi‐Wei Tang, Hongzhou Lu   +2 more
wiley   +1 more source