Results 181 to 190 of about 2,401,578 (298)

Assembloid learning: opportunities and challenges for personalized approaches to brain functioning in health and disease

Frontiers in Artificial Intelligence
Arianna Mencattini, Arianna Mencattini, Elena Daprati, David Della-Morte, David Della-Morte, Fiorella Guadagni, Fiorella Guadagni, Federica Sangiuolo, Eugenio Martinelli, Eugenio Martinelli   +9 more
doaj   +1 more source

Biomaterials in organoid research: current state and future directions. [PDF]

Front Bioeng Biotechnol
Klasen L, Nasehi R, Selzener L, De Laporte L.   +3 more
europepmc   +1 more source

National Intelligence Daily (Cable) 5 March 1982

, 1982
Declassified on 2017-11 ...
United States. Central Intelligence Agency.
core  

Current Advances of Treatments, Therapeutic Targets, Biomarkers, Novel Drugs, and Machine Learning for Hypopharyngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Hypopharyngeal squamous cell carcinoma (HSCC) is an aggressive subtype of head and neck squamous cell carcinoma with insidious onset, early metastasis, and dismal prognosis. Conventional multimodal therapy achieves limited survival benefit, highlighting an urgent need for refined precision strategies.
Ce Li, Rui Guan, Rui‐Jie Jiao, Zhi‐Jie Bi, Yang Fu, Yin Wang, Chen‐Yang Xu, Ye Qian, Ran Wei, Sheng‐Da Cao, Wen‐Ming Li, Dong‐Min Wei, Da‐Peng Lei   +12 more
wiley   +1 more source

Integrating Next-Generation Reproductive Organoids with Genomics, Multi-Omics and Bioengineering to Understand Human Infertility. [PDF]

Genes (Basel)
Barreau P, Djari C, De Vos J, Cassuto NG, Assou S.   +4 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Using Brain Organoids to Explore Human Neurobiology. [PDF]

Cell Mol Neurobiol
Marei HE, Hasan A.
europepmc   +1 more source

Virtual cell construction for artificial intelligence‐driven drug discovery

British Journal of Pharmacology, EarlyView.
Cells are the fundamental units through which genetic variation and pharmacological perturbations influence disease processes and therapeutic responses. However, cellular responses to intervention are strongly shaped by biological context, creating a central challenge for drug discovery: predicting how specific perturbations reshape cellular systems ...
Yuran Jia, Xiao Xing, Haoyang Han, Yuansong Zhao, Shiyao Zhou, Jingjing Chen   +5 more
wiley   +1 more source

Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections. [PDF]

Front Pharmacol
Makkar SK, Bhatia S, Nguyen N, Wei G.
europepmc   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source