Results 191 to 200 of about 2,401,578 (298)

Artificial intelligence virtual bone organoids (AIVBOs). [PDF]

J Orthop Translat
Ding N, Yu B, Lyu X, Xu K, Geng Z, Su J, Bai L.   +6 more
europepmc   +1 more source

Liver Organoids: From Disease Modelling to Regenerative Medicine

Cell Proliferation, EarlyView.
Liver organoids provide a versatile platform for disease modelling and drug discovery, leveraging stem cells and engineering techniques. They bridge research and clinical applications, offering significant potential for advancing precision medicine and regenerative therapies for liver diseases.
Tiepeng Wang, Xiaotian Qu, Jinhong Si, Junkang Meng, Ting Zhang, Shuliang Niu   +5 more
wiley   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

organoid-oi v3: A Biologically Grounded Closed-Loop Framework for Organoid Intelligence Simulation

We present organoid-oi v3, an open-source Python framework for simulating closed-loop visual categorical learning in a synthetic brain organoid. The system implements Three-Factor Spike-Timing-Dependent Plasticity (STDP) with biologically realistic reward and penalty delivery: reward is a 10 Hz sub-threshold theta depolarization current producing ...
openaire   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

20th Anniversary of human‐induced pluripotent stem cells and the role of microscopy

Journal of Microscopy, EarlyView.
Abstract It has been 20 years since the pioneering work of Shinya Yamanaka and Kazutoshi Takahashi at Kyoto University led to the first successful generation of induced pluripotent stem cells (iPSCs) from mouse embryonic and adult fibroblast cells. iPSCs have the capacity to differentiate into any type of cell in the human body, and as such, they have ...
Philomena Hallford, Colette J. Mustard, Nicole Brace, Antonia L. Pritchard   +3 more
wiley   +1 more source

Patient-derived organoids in functional precision oncology: from experimental models to clinical decision-making. [PDF]

Front Endocrinol (Lausanne)
Caruso A, Delvecchio A, Memeo R, Lanzino M, Martinotti S.   +4 more
europepmc   +1 more source

Thrombosis and Circulation: From Bench to Bedside

Thrombosis and Circulation Research, EarlyView.
Zhenguo Zhai
wiley   +1 more source

The reproducibility gap in graph neural network workflows for cell dynamics: A checklist‐driven case study

Journal of Microscopy, EarlyView.
Abstract As part of a Global BioImage Analysts' Society (GloBIAS) initiative, we evaluated the reproducibility of a Graph Neural Network (GNN) study on cell dynamics using structured, community‐developed checklists from the Quality Assessment and Reproducibility for Instruments and Images in Light Microscopy (QUAREP‐LiMi) initiative.
Martin Schätz, Ko Sugawara
wiley   +1 more source

Editorial: Innovative approaches for disease modeling using organoids and organ-on-a-chip. [PDF]

Front Bioeng Biotechnol
Valkai S.
europepmc   +1 more source