Results 161 to 170 of about 112,967 (355)

A Modular Perfusion Bioreactor Platform for Simulating Bone Regeneration and Fracture Healing: Integrating Mechanical Loading and Dual Perfusion for Advanced In Vitro Models

Advanced Healthcare Materials, EarlyView.
A modular bioreactor platform was developed in order to replicate bone homeostasis and pathology, thereby integrating mechanical loading, dynamic perfusion, and a 3D‐printed microfluidic chamber. With precise control of environmental parameters and dual perfusion for composite tissue models, the system enhances physiological relevance for studying bone
Moritz Pfeiffenberger, Alexandra Damerau, Johannes Plank, Adel Ahmed, Mario Thiele, Jan Saam, Paula Hoff, Timo Gaber, Frank Buttgereit   +8 more
wiley   +1 more source

Precision Medicine for Gastric Cancer: Current State of Organoid Drug Testing

Organoids
Gastric cancer (GC) presents a significant health challenge and ranks as the fifth most common cancer in the world. Unfortunately, most patients with GC exhaust standard care treatment options due to late diagnosis and tumour heterogeneity that leads to ...
Tharindie N. Silva, Josephine A. Wright, Daniel L. Worthley, Susan L. Woods   +3 more
doaj   +1 more source

Stable expansion of high-grade serous ovarian cancer organoids requires a low-Wnt environment

, 2020
Berger, H., Braicu, E., Chekerov, R., Darb-Esfahani, S., Hoffmann, K., Kessler, M., Kulbe, H., Mangler, M., Meyer, T., Mollenkopf, H., Sehouli, J., Taube, E., Thillainadarasan, S., Zemojtel, T.   +13 more
core   +1 more source

An unusual organoid tumor. Alveolar soft part sarcoma or paraganglioma?

, 1991
Debra S. Heller, Cheryl Frydman, Ronald E. Gordon, Jashree Jagirdar, Ira S. Schwartz   +4 more
openalex   +1 more source

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium [PDF]

, 2011
Toshiro Sato, Daniel E. Stange, Marc Ferrante, Robert G.J. Vries, Johan H. van Es, Stieneke van den Brink, Winan J. van Houdt, Apollo Pronk, Joost van Gorp, Peter D. Siersema, Hans Clevers   +10 more
openalex   +1 more source

Transforming Cancer Diagnosis and Therapy Through Fluorescent Hydrogels: A Review

Advanced Healthcare Materials, EarlyView.
This article reviews fluorescent hydrogel systems for cancer detection, monitoring, and therapy. Mimicking the tumor microenvironment, these hydrogels enable real‐time imaging and targeted drug delivery. The review discusses design strategies, labeling techniques, and applications, highlighting challenges and future opportunities in cancer diagnostics ...
Elahe Masaeli, Seshasai Srinivasan, Amin Reza Rajabzadeh   +2 more
wiley   +1 more source

Establishment and Validation of Patient-Derived Non-Small Cell Lung Cancer Organoids as In Vitro Lung Cancer Models

Organoids
Background: Recent advances in the personalized treatment of non-small cell lung cancer (NSCLC) require representative in vitro model systems that reflect tumor heterogeneity and maintain the characteristic genetic aberrations.
Raphael S. Werner, Jae-Hwi Jang, Markus Rechsteiner, Michaela B. Kirschner, Isabelle Opitz   +4 more
doaj   +1 more source

Chromatin establishes an immature version of neuronal protocadherin selection during the naive-to-primed conversion of pluripotent stem cells. [PDF]

, 2019
In the mammalian genome, the clustered protocadherin (cPCDH) locus provides a paradigm for stochastic gene expression with the potential to generate a unique cPCDH combination in every neuron.
Allegue, Catarina, Almenar-Queralt, Angels, Bohaciakova, Dasa, Chaves, Rodrigo S, Chen, Andrew G, Dittrich, Marcus, Driscoll, Shawn P, El Hajj, Nady, Fong, Lauren K, Garcia-Bassets, Ivan, Goldstein, Lawrence SB, Hruska-Plochan, Marian, Kim, Hong Sook, Kohlnhofer, Bridget, Ma, Qi, Mackintosh, Carlos, Marsala, Martin, Merkurjev, Daria, Navarro, Michael, Tadokoro, Takahiro, Woodruff, Grace, Young, Jessica E   +21 more
core  

Engineering Complexity: Advances in 3D Breast Cancer Models for Precision Oncology

Advanced Healthcare Materials, EarlyView.
In vitro breast cancer models that closely mimic the complex biological and cellular interactions within the tumor microenvironment hold strong promise for enhancing our understanding of tumor progression, immune system behavior, and resistance to therapies, which are essential for developing personalized cancer treatments. Abstract Engineered in vitro
Wonwoo Jeong, Sang Jin Lee
wiley   +1 more source

From organoids to gastruloids

, 2017
Last year was hailed as ‘the year of the organoid’ as news of mini- brains, livers and intestines grown in the laboratory hit the headlines. Here, Dr David Turner explains the latest in vitro systems for modelling human development and disease, including embryonic stem cells, organoids and ...
openaire   +3 more sources