Results 141 to 150 of about 82,310 (303)

Geometrically-Inverted Organoids

, 2023
To minimize the cost, ethics, and species-specific variations associated with animal models, in vitro models are gradually becoming adopted, as they have improved our understanding of both normal and diseased organ function.
Parigoris, Eric
core  

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Functional Precision Oncology in Rectal Cancer Liver Metastasis: Integrated Genomic and Organoid-Based Drug Sensitivity Profiling

Organoids
Treatment-refractory rectal cancer liver metastasis represents a major therapeutic challenge, particularly in the absence of actionable genomic biomarkers.
Ebrar Tutar-Torun, Begüm Kurt, Dila Sener-Akcora, Ayse Mine Yilmaz, Ali Sahin, Kazım Yalcin Arga, Muharrem Okan Cakir, Taha Bahsi, Mustafa Ozdogan, Betul Karademir-Yilmaz   +9 more
doaj   +1 more source

Establishment of Stable Knockdown of MACC1 Oncogene in Patient-Derived Ovarian Cancer Organoids

High-grade serous ovarian cancer (HGSOC) remains the most lethal gynecological malignancy, and there is still an unmet medical need to deepen basic research on its origins and mechanisms of progression.
Mirjana Kessler, Fabian Trillsch, Sophia Hierlmayer, Christoph Klein, Juliane Reichenbach, Anca Chelariu-Raicu, Liliia Hladchenko, Sven Mahner   +7 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Organoids, Biocybersecurity, and Cyberbiosecurity—A Light Exploration

Organoids
Organoids present immense promise for studying organ systems and their functionality. Recently, they have become the subject of exploration outside of purely biomedical uses in multiple directions.
Xavier Palmer, Cyril Akafia, Eleasa Woodson, Amanda Woodson, Lucas Potter   +4 more
doaj   +1 more source

Establishment of biliopancreatic cancer patient-derived organoids and propagation from biliary cultures: preliminary results from the Bile Biopsy study

reservedIntroduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies, ranking as the seventh leading cause of cancer-related deaths globally. Despite extensive research efforts, its prognosis remains dismal,
PALANO, GIORGIO
core  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Dysregulated Intestinal Nutrient Absorption in Obesity Is Associated with Altered Chromatin Accessibility

Organoids
Obesity is an epidemic with myriad health effects, but little is understood regarding individual obese phenotypes and how they may respond to therapy. Epigenetic changes associated with obesity have been detected in blood, liver, pancreas, and adipose ...
Dilhana S. Badurdeen, Zhen Li, Jeong-Heon Lee, Tao Ma, Aditya Vijay Bhagwate, Rachel Latanich, Arjit Dogiparthi, Tamas Ordog, Olga Kovbasnjuk, Vivek Kumbhari, Jennifer Foulke-Abel   +10 more
doaj   +1 more source

Bioengineered Tubular Biliary Organoids

Liver organoids have emerged as promising in vitro models for toxicology, drug discovery, and disease modeling. However, conventional 3D epithelial organoid culture systems suffer from significant drawbacks, including limited culture duration, a ...
Elci, Bilge Sen, Rezakhani, Saba, Lutolf, Matthias P, Nikolaev, Mikhail   +3 more
core   +1 more source