Results 131 to 140 of about 82,310 (303)

Precision Oncology at a Crossroads: How Organoid Platforms Are Reshaping the Field

Organoids
Tumor heterogeneity and microenvironmental complexity remain fundamental barriers to genomics-centered precision oncology, frequently causing discordance between molecular alterations and real-world therapeutic responses.
Seulbee Lee, Alyssa Kim, Rachel Hyunkyung Kim, Seo-Hee You, Hyun Soo Kim, Seok Chung, Sang-Haak Lee, Seung-Ah Yahng, In Kyoung Kim, Hye Joung Kim   +9 more
doaj   +1 more source

Venomous organoids [PDF]

Nature Methods, 2020
openaire   +2 more sources

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Sulfonic DJ-1 (Cys¹⁰⁶-SO₃H) Binds to and Colocalizes with the Intracellular Accumulation of Amyloid-Beta 42 (Aβ42) in Familial Alzheimer’s Disease PSEN1 E280A Cerebral Organoids Derived from Induced Pluripotent Stem Cells

Organoids
The intracellular accumulation of amyloid beta 42 (iAβ42) has been proposed as an early pathological indicator of familial Alzheimer’s disease (FAD).
Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio   +3 more
doaj   +1 more source

3D-Organoid-SwinNet: High-Content Profiling of 3D Organoids

IEEE Journal of Biomedical and Health Informatics
Profiling of Patient-Derived organoids is necessary for drug screening and precision medicine. This step requires accurate segmentation of three-dimensional cellular structures followed by protein readouts. While fully Convolutional Neural Networks are widely used in medical image segmentation, they struggle to capture long-range dependencies necessary
Muhammad Sohaib, Siyavash Shabani, Sahar A. Mohammed, Bahram Parvin   +3 more
openaire   +2 more sources

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Engineering Chimeric Cardio-Vascular Assembloids Using Human iPSC-Derived Cardiomyocytes and Vascular Rings

Organoids
The myocardium possesses one of the highest vascular densities in the body. The outermost wall layer of large and medium-sized vessels, the adventitia, forms a critical interface between the vasculature and the myocardium and serves as a reservoir for ...
Hannah Klör, Kornelia Kenst, Berin Upcin, Süleyman Ergün, Philipp Wörsdörfer   +4 more
doaj   +1 more source

Evolution of organoid genetics

European Journal of Cell Biology
Organoids have revolutionized in vitro research by offering three-dimensional, multicellular systems that recapitulate the structure, function, and genetics of human tissues. Initially developed from both pluripotent stem cells (PSCs) and adult stem cells (AdSCs), organoids have expanded to model nearly every major human organ, significantly advancing ...
Thomas M. Klompstra, Ki-Jun Yoon, Bon-Kyoung Koo   +2 more
openaire   +3 more sources

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

A Pan-Cancer Preclinical Validation Framework for Organoid-Based Drug Sensitivity Testing

Organoids
Patient-derived organoids (PDOs) provide ex vivo functional models that capture tumor drug-response patterns across multiple cancer types. Organoid drug sensitivity testing (ODST) has accumulated supportive evidence in single-tumor studies, yet it lacks ...
Jia Shang, Caixia Xia, Zilin Xu, Sheng Tu, Gang Li, Fangjin Chen, Lingao Ju, Gang Wang, Yu Xiao, Kaiyu Qian   +9 more
doaj   +1 more source