Results 111 to 120 of about 94,019 (259)

In‐House Manufacturing of 3D ECM Culture Chips via Vacuum Thermoforming for Enhanced Imaging Applications

Advanced Materials Technologies, EarlyView.
Desktop vacuum thermoforming enables rapid, low‐cost fabrication of 96‐channel polystyrene culture chips with very thin imaging interfaces. The resulting platform supports cell lines, primary cells, and patient‐derived organoids, and enables high‐resolution confocal microscopy and single‐cell visualization, providing an accessible approach for advanced
Aleksandra Fomina, Adam Tam, Jennifer Lam, Nila C. Wu, Nancy T. Li, Alison P. McGuigan   +5 more
wiley   +1 more source

Organoids in cancer research

, 2018
The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological human cancer models. Such preclinical models are essential for more efficient translation of basic cancer
CMM Sectie Molecular Cancer Research, Regenerative Medicine and Stem Cells, Clevers, Hans, Drost, Jarno, Child Health, Hubrecht Institute with UMC, Cancer   +6 more
core   +2 more sources

A Fully Annotated Hepatoblastoma Tumoroid Biobank Details Treatment-Induced Evolution and Clonal Dynamics in Paediatric Cancer Patients

Organoids
Hepatoblastoma (HB) is a paediatric liver malignancy arising from hepatic precursor cells, with >90% of cases harbouring a mutation in exon 3 of CTNNB1. We present a fully genetically characterised HB tumour organoid (tumoroid) biobank, which allows for ...
Gijs J. F. van Son, Femke C. A. S. Ringnalda, Markus J. van Roosmalen, Thomas A. Kluiver, Quinty Hansen, Evelien Duiker, Marius C. van den Heuvel, Vincent E. de Meijer, Ruben H. de Kleine, Ronald R. de Krijger, József Zsiros, Weng Chuan Peng, Ruben van Boxtel, Marc van de Wetering, Karin Sanders, Hans Clevers   +15 more
doaj   +1 more source

Recent Advances in Transparent Microelectrode Device Architecture and Fabrication Strategies for Biomedical Applications

Advanced Materials Technologies, EarlyView.
Transparent microelectrode arrays enable simultaneous optical and electrical electrophysiology with high spatiotemporal resolution, allowing multimodal observations of dynamic biological systems. Advances in materials and device architectures improve device performance by addressing key trade‐offs between optical transparency, impedance, and ...
Michael Abraham Listyawan, Tran Bach Dang, Chi Cong Nguyen, Yee Lap Pong, Tianruo Guo, Thanh Nho Do, Hoang‐Phuong Phan   +6 more
wiley   +1 more source

Analysis of Osteosarcoma Cell Lines and Patient Tissue Using a 3D In Vivo Tumor Model—Possible Effects of Punicalagin

Organoids
Osteosarcomas are the most common primary malignant bone tumors and mostly affect children, adolescents, and young adults. Despite current treatment options such as surgery and polychemotherapy, the survival of patients with metastatic disease remains ...
Anna Rebecca Dorn, Sara Neff, Sophia Hupp, Melissa Engelhardt, Eric Pion, Ulrich Lenze, Carolin Knebel, Anna Duprée, Simone Schewe, Markus Weber, Christian Wulbrand, Axel Hillmann, Florian Weber, Phillip Clarke, Philipp Kainz, Thiha Aung, Silke Haerteis   +16 more
doaj   +1 more source

Quercetin Promote the Chemosensitivity in Organoids Derived from Patients with Breast Cancer [PDF]

Shengwen Meng,1 Yifan Cao,1 Lei Lu,1 Xuanhe Li,1 Siyu Sun,1 Fangqian Jiang,1 Jianfei Lu,2 Dongwei Fan,3 Xinxin Han,1 Tingjing Yao1 1Department of Surgical Oncology, The Fourth Ward of Breast and Thyroid, the First Affiliated Hospital of Bengbu Medical ...
Lu L, Li X, Meng S, Jiang F, Cao Y, Sun S, Lu J, Yao T, Han X, Fan D   +9 more
core  

Liquid Metal Resistive Sensing Architectures for Measuring Diaphragm Strain Responses on Obstructed Surfaces

Advanced Materials Technologies, EarlyView.
A liquid metal‐based strain‐sensing architecture to measure the deformation of a circular diaphragm against obstructed surfaces is formulated using finite element modeling and confocal imaging to establish the mechanical framework and is utilized to control diaphragm‐induced confinement on a bead array, as validated by biomolecular loading level ...
Abdullah‐Bin Siddique, Jui‐Hong Weng, Deng‐Kai Yang, Chia‐Fu Chou, Nathan S. Swami   +4 more
wiley   +1 more source

Turning Light Into Matter: Programmable Microstructures Via Dose Control in Two‐Photon Polymerization

Advanced Optical Materials, EarlyView.
This work augments two‐photon polymerization with point‐wise dose control, enabling structures with heterogeneous material properties such as refractive index. An open source toolbox and superior calibration methodology for the refractive index pave the way for bio‐mimicking or numerically optimized structure designs, and enhance the synergy between 3D
Michał Ziemczonok, Koen Vanmol
wiley   +1 more source

A Method to Study Migration and Invasion of Mouse Intestinal Organoids

Organoids
Colorectal cancer (CRC) is the third most common cancer worldwide and it is the second leading cause of cancer death. In CRC, as in most cancers, the formation of metastasis through the migration and invasion of cancer cells to distant organs is ...
Valérie M. Wouters, Ciro Longobardi, Jan Paul Medema   +2 more
doaj   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source