Results 211 to 220 of about 112,967 (355)

Organoid Models of Human Gastrointestinal Development and Disease [PDF]

, 2016
Priya H. Dedhia, Nina Bertaux‐Skeirik, Yana Zavros, Jason R. Spence   +3 more
openalex   +1 more source

Possibilities of Inner Ear Barrier Models for Otologic Drug Development

Advanced Therapeutics, EarlyView.
This review examines innovative organ chip models that reconstruct critical inner ear barriers, addressing a fundamental challenge in otologic drug development: the limited understanding of pharmaceutical behavior across these complex barriers. By replicating these barriers, the advanced models offer promising alternatives to traditional testing ...
Yeji Ahn, Seonmin Choi, Minju Kim, Zachary Estlack, Daniel Brown, Jaehong Key, Young Joon Seo, Jungkyu Kim   +7 more
wiley   +1 more source

Animal-free alternatives for Matrigel in human iPSC-derived blood vessel organoid culture. [PDF]

Sci Rep
Giles R, Meijer EM, Maas RGC, van Dijk CGM, Verhaar MC, Cheng C.   +5 more
europepmc   +1 more source

Vps35∆/∆ organoids show a growth defect but are competent to respond to Wnt signaling.

, 2013
E. A. de Groot Reinoud, F. Farin Henner, Macůrková Marie, H. van Es Johan, Clevers Hans, C. Korswagen Hendrik   +5 more
openalex   +1 more source

XBP1s Mediates Cross‐resistance to Combination Treatment of CDK4/6 Inhibitors plus Endocrine Therapy in Breast Cancer

Advanced Science, EarlyView.
Elevated spliced form of X‐box–binding protein 1 (XBP1) correlates with unfavorable responses to endocrine therapy plus CDK4/6 inhibitors in HR+/HER2− advanced breast cancer. XBP1s facilitates cell proliferation and G1/S transition by transcriptionally activating SND1, thereby activating the E2F1 pathway.
Yuting Sang, Shiyang Liu, Xujie Zhou, Weiru Chi, Min Xiong, Ming Chen, Hengyu Ren, Douwaner Liu, Liyi Zhang, Jingyan Xue, Yayun Chi, Jiong Wu   +11 more
wiley   +1 more source

STAG2 mutations in the normal colon induce upregulation of oncogenic pathways in neighbouring wildtype cells. [PDF]

PLoS One
Yew WN, Dean CJ, Chan DKH.
europepmc   +1 more source

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

, 2014
Sylvia F. Boj, Chang‐Il Hwang, Lindsey A. Baker, Iok In Christine Chio, Dannielle D. Engle, Vincenzo Corbo, Myrthe Jager, Mariano Ponz‐Sarvisé, Hervé Tiriac, Mona S. Spector, Ana Gudelj Gračanin, Tobiloba E. Oni, Kenneth H. Yu, Ruben van Boxtel, Meritxell Huch, Keith Rivera, John P. Wilson, Michael E. Feigin, Daniel Öhlund, Abram Handly-Santana, Christine Ardito-Abraham, Michael Ludwig, Ela Elyada, Brinda Alagesan, Giulia Biffi, Georgi N. Yordanov, Bethany Delcuze, Brianna Creighton, Kevin Wright, Youngkyu Park, Folkert H.M. Morsink, I. Quintus Molenaar, Inne H. Borel Rinkes, Edwin Cuppen, Hao Yuan, Ying Jin, Isaäc J. Nijman, Christine A. Iacobuzio‐Donahue, Steven D. Leach, Darryl Pappin, Molly Hammell, David S. Klimstra, Olca Baştürk, Ralph H. Hruban, G. Johan A. Offerhaus, Robert G. Vries, Hans Clevers, David A. Tuveson   +47 more
openalex   +1 more source

M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits

Advanced Science, EarlyView.
Genes associated with endometriosis risk are highly expressed in M2 macrophages, particularly ligands IL1A and IL1B. Endometrial‐type epithelium and stroma are likely recipients of these ligands. While IL1B treatment disturbs epithelial organization, blockage of the signaling results in a dose‐dependent decrease in spontanesous and evoked pain, reduces
Soledad Ochoa, Fernanda S. Rasquel‐Oliveira, Brett McKinnon, Marcela Haro, Sugarniya Subramaniam, Pak Yu, Simon Coetzee, Michael S. Anglesio, Kelly N. Wright, Raanan Meyer, Anne E. Porter, Caroline E. Gargett, Sally Mortlock, Grant W. Montgomery, Michael S. Rogers, Kate Lawrenson   +15 more
wiley   +1 more source

Generation of Agarose-Based FFPE Cancer Organoids for Morphology Preservation. [PDF]

Bio Protoc
Lee MR, Kang S, Jeon AR, Choi SW, Kong SY, Kim YH.   +5 more
europepmc   +1 more source

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

, 2014
Dong Gao, Ian Vela, Andrea Sboner, Phillip J. Iaquinta, Wouter R. Karthaus, Anuradha Gopalan, Catherine Dowling, Jackline Wanjala, Eva A. Undvall, Vivek Arora, John Wongvipat, Myriam Kossaï, Sinan Ramazanoglu, Luendreo P. Barboza, Wei Di, Zhen Cao, Qi Fan Zhang, Inna Sirota, Leili Ran, Theresa Y. MacDonald, Himisha Beltran, Juan‐Miguel Mosquera, Karim Touijer, Peter T. Scardino, Vincent P. Laudone, Kristen Curtis, Dana E. Rathkopf, Michael J. Morris, Daniel C. Danila, Susan F. Slovin, Stephen B. Solomon, James A. Eastham, Ping Chi, Brett S. Carver, Mark A. Rubin, Howard I. Scher, Hans Clevers, Charles L. Sawyers, Yu Chen   +38 more
openalex   +1 more source