Results 51 to 60 of about 6,002 (159)

The DnaA Cycle in Escherichia coli: Activation, Function and Inactivation of the Initiator Protein

Frontiers in Microbiology, 2017
This review summarizes the mechanisms of the initiator protein DnaA in replication initiation and its regulation in Escherichia coli. The chromosomal origin (oriC) DNA is unwound by the replication initiation complex to allow loading of DnaB helicases ...
Tsutomu Katayama, Kazutoshi Kasho, Hironori Kawakami   +2 more
doaj   +1 more source

Initiation of chromosomal replication in predatory bacterium Bdellovibrio bacteriovorus

Frontiers in Microbiology, 2016
Bdellovibrio bacteriovorus is a small Gram-negative predatory bacterium that attacks other Gram-negative bacteria, including many animal, human, and plant pathogens.
Lukasz Makowski, Rafal Donczew, Christoph Weigel, Anna Magdalena Pawlik, Jolanta Zakrzewska-Czerwinska   +4 more
doaj   +1 more source

Control regions for chromosome replication are conserved with respect to both sequence and location between Escherichia coli strains

Frontiers in Microbiology, 2015
In Escherichia coli, chromosome replication is initiated from oriC by the DnaA initiator protein associated with ATP. Three non-coding regions contribute to the activity of DnaA.
Jakob eFrimodt-Møller, Godefroid eCharbon, Karen A. Krogfelt, Anders eLøbner-Olesen   +3 more
doaj   +1 more source

Cooperation between two modes for DNA replication initiation in the archaeon Thermococcus barophilus

mBio
The mechanisms underpinning the replication of genomic DNA have recently been challenged in Archaea. Indeed, the lack of origin of replication has no deleterious effect on growth, suggesting that replication initiation relies on homologous recombination.
Logan Mc Teer, Yann Moalic, Valérie Cueff-Gauchard, Ryan Catchpole, Gaëlle Hogrel, Yang Lu, Sébastien Laurent, Marie Hemon, Johanne Aubé, Elodie Leroy, Erwan Roussel, Jacques Oberto, Didier Flament, Rémi Dulermo   +13 more
doaj   +1 more source

The Stringent Response Inhibits DNA Replication Initiation in E. coli by Modulating Supercoiling of oriC

mBio, 2019
The stringent response enables bacteria to respond to a variety of environmental stresses, especially various forms of nutrient limitation. During the stringent response, the cell produces large quantities of the nucleotide alarmone ppGpp, which ...
James A. Kraemer, Allen G. Sanderlin, Michael T. Laub   +2 more
doaj   +1 more source

Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella

mBio, 2018
Highly expressed genes are commonly located close to the origin of replication of bacterial chromosomes (OriC). This location skew is thought to reflect selective advantages associated with gene dosage effects during the replication cycle. The expression
Eva Garmendia, Gerrit Brandis, Diarmaid Hughes   +2 more
doaj   +1 more source

A novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death

Blood Cancer Journal
Highlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decreases ...
Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson   +19 more
doaj   +1 more source

Role, Importance of ORIC and Entrepreneurship in Universities

Pakistan Journal of Medicine and Dentistry, 2020
The entrepreneurial universities aim to facilitate practical knowledge to students and industries to foster economic development. Many ideas were put forward to pioneer universities in the United States like Massachusetts Institute of Technology (MIT) and Stanford, and establish a solid patent policy, technology transfer policy and Liaison between ...
openaire   +2 more sources

The Escherichia coli cryptic prophage protein YfdR binds to DnaA and initiation of chromosomal replication is inhibited by overexpression of the gene cluster yfdQ-yfdR-yfdS-yfdT

Frontiers in Microbiology, 2016
The initiation of bacterial chromosomal replication is regulated by multiple pathways. To explore novel regulators, we isolated multicopy suppressors for the cold-sensitive hda-185 ΔsfiA(sulA) mutant.
Yaunori eNoguchi, Tsutomu eKatayama
doaj   +1 more source

Organizational readiness for change towards implementing a sepsis survivor hospital to home transition-in-care protocol

Frontiers in Health Services
BackgroundOrganizational readiness for change, defined as the collective preparedness of organization members to enact changes, remains understudied in implementing sepsis survivor transition-in-care protocols.
Elaine Sang, Elaine Sang, Ryan Quinn, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Michael A. Stawnychy, Jiyoun Song, Jiyoun Song, Jiyoun Song, Karen B. Hirschman, Karen B. Hirschman, Karen B. Hirschman, Sang Bin You, Sang Bin You, Katherine S. Pitcher, Katherine S. Pitcher, Nancy A. Hodgson, Nancy A. Hodgson, Nancy A. Hodgson, Patrik Garren, Melissa O'Connor, Sungho Oh, Sungho Oh, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles, Kathryn H. Bowles   +27 more
doaj   +1 more source