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Orientia tsutsugamushi: A life between escapes. [PDF]

Microbiologyopen, 2023
The life cycle of the mite‐borne, obligate intracellular pathogen Orientia tsutsugamushi (Ot), the causative agent of human scrub typhus, differs in many aspects from that of other members of the Rickettsiales order.
Fromm L, Mehl J, Keller C.
europepmc   +6 more sources

Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis [PDF]

Pathogens
Scrub typhus is an emerging chigger-borne disease caused by the obligate intracellular bacterium Orientia tsutsugamushi. Necroptosis is a form of programmed cell death (PCD) mediated by RIPK3 (serine/threonine kinase receptor interacting protein 3) and ...
Thomas E. Siff, Paige E. Allen, David L. Armistead, Jason R. Hunt, Steven J. Rolland, Hervé Agaisse, Jason A. Carlyon   +6 more
doaj   +3 more sources

Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche [PDF]

Nature Communications
Infections by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that ultimately eliminate the damaged cell and hence the microbial niche.
Paige E. Allen, David L. Armistead, Svetlana Blinova, Jason A. Carlyon   +3 more
doaj   +3 more sources

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression [PDF]

Nature Communications
How intracellular bacteria subvert the major histocompatibility complex (MHC) class I pathway is poorly understood. Here, we show that the obligate intracellular bacterium Orientia tsutsugamushi uses its effector protein, Ank5, to inhibit nuclear ...
Haley E. Adcox, Jason R. Hunt, Paige E. Allen, Thomas E. Siff, Kyle G. Rodino, Andrew K. Ottens, Jason A. Carlyon   +6 more
doaj   +3 more sources

Case Report: Encephalitis with Initial Manifestation of Orientia Tsutsugamushi Infection Detected by Metagenomic Next-Generation Sequencing [PDF]

Infection and Drug Resistance
Song Han,1,* Suge Yang,1,* Yun Wang,2 Yingying Xu2 1The Second Hospital of Shandong University, Cheeloo College of Medicine of Shandong University, Shandong University, Jinan, 250033, People’s Republic of China; 2Department of Neurology Medicine,
Han S, Yang S, Wang Y, Xu Y
doaj   +3 more sources

A Novel Genotype of Orientia tsutsugamushi in Human Cases of Scrub Typhus from Southeastern India. [PDF]

Microorganisms
Scrub typhus is a mite-borne, re-emerging public health problem in India, particularly in Tamil Nadu, South India. More than 40 serotypes of Orientia tsutsugamushi have been documented worldwide.
Nallan K, Kalidoss BC, Jacob ES, Mahadevan SK, Joseph S, Ramalingam R, Renu G, Thirupathi B, Ramasamy B, Gupta B, Rahi M, Rajaiah P.   +11 more
europepmc   +2 more sources

<i>Orientia tsutsugamushi</i> alters the intranuclear balance of cullin-1 and c-MYC to inhibit apoptosis. [PDF]

Infect Immun
Cullin-1 (Cul1), a cullin–RING ubiquitin ligase component, represses c-MYC activity in the nucleus. Orientia tsutsugamushi causes the potentially fatal rickettsiosis, scrub typhus. The obligate intracellular bacterium encodes an arsenal of ankyrin repeat-
Allen PE, Adcox HE, Siff TE, Gupta S, Hunt JR, Carlyon JA.   +5 more
europepmc   +2 more sources

Geographic distribution of Orientia tsutsugamushi strains on chigger mites in the Republic of Korea (2021-2023). [PDF]

Parasit Vectors
Scrub typhus is caused by the larvae of chigger mites infected with Orientia tsutsugamushi, and many cases are reported globally. The virulence and prevalence of O. tsutsugamushi varies depending on the strain and region.
Lee HS, Noh BE, Kim H, Lee H.
europepmc   +2 more sources

The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility. [PDF]

Nat Commun
The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and the motor protein dynein to traffic to the perinuclear region within infected cells.
Manigrasso G, Saharat K, Chaichana P, Kullapanich C, Atwal S, Boulanger J, Morgan TE, Kramer H, Salje J, Carter AP.   +9 more
europepmc   +2 more sources

Molecular diagnosis and genotyping of Orientia tsutsugamushi in Maesot and Chiangrai, Thailand. [PDF]

Front Trop Dis, 2023
Introduction Scrub typhus is a neglected tropical disease with an estimated 1 million cases annually. The Asia-Pacific region is an endemic area for scrub typhus, especially in Thailand. Methods Between June 2018 and December 2019, 31 patients with acute
Rungrojn A, Batty EM, Perrone C, Abdad MY, Wangrangsimakul T, Brummaier T, McGready R, Day NPJ, Blacksell SD.   +8 more
europepmc   +2 more sources