Antigenic Relationships among Human Pathogenic Orientia tsutsugamushi Isolates from Thailand. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Scrub typhus is a common cause of undiagnosed febrile illness in certain tropical regions, but can be easily treated with antibiotics. The causative agent, Orientia tsutsugamushi, is antigenically variable which complicates diagnosis and ...
Sarah L James +6 more
doaj +11 more sources
Orientia tsutsugamushi Modulates RIPK3 Cellular Levels but Does Not Inhibit Necroptosis [PDF]
PathogensScrub typhus is an emerging chigger-borne disease caused by the obligate intracellular bacterium Orientia tsutsugamushi. Necroptosis is a form of programmed cell death (PCD) mediated by RIPK3 (serine/threonine kinase receptor interacting protein 3) and ...
Thomas E. Siff +6 more
doaj +2 more sources
Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner. [PDF]
PLoS ONE, 2012 Orientia tsutsugamushi, a causative agent of scrub typhus, is an obligate intracellular bacterium, which escapes from the endo/phagosome and replicates in the host cytoplasm. O.
Jung-Eun Koo +4 more
doaj +6 more sources
Utility of next-generation sequencing for the etiological diagnosis of Orientia tsutsugamushi infection [PDF]
Infectious MedicineBackground: Scrub typhus, an acute febrile disease caused by Orientia tsutsugamushi, is transmitted to humans through infected chigger mites. We present a case of scrub typhus in a previously healthy man from Shandong Province diagnosed using next ...
Nannan Xu +4 more
doaj +2 more sources
Assessment of a Sensitive qPCR Assay Targeting a Multiple-Copy Gene to Detect Orientia tsutsugamushi DNA [PDF]
Tropical Medicine and Infectious Disease, 2019 Scrub typhus is caused by an obligated intracellular organism, Orientia tsutsugamushi (Orientia). The disease was traditionally thought to be limited in the tsutsugamushi triangle.
Chien-Chung Chao +4 more
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Orientia tsutsugamushi modulates p53, the cell cycle, and genotoxicity to maintain its intracellular niche [PDF]
Nature CommunicationsInfections by intracellular pathogens often cause insult to host cell DNA, which stimulates responses that ultimately eliminate the damaged cell and hence the microbial niche.
Paige E. Allen +3 more
doaj +2 more sources
PLoS ONE, 2018 Scrub typhus is a mites-borne rickettsiosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. The disease is potentially life threatening and is prevalent in tropical Asia, islands of the western Pacific Ocean and ...
Loganathan Ponnusamy +8 more
doaj +3 more sources
New Orientia tsutsugamushi Strain from Scrub Typhus in Australia
Emerging Infectious Diseases, 1998 In a recent case of scrub typhus in Australia, Orientia tsutsugamushi isolated from the patient's blood was tested by sequence analysis of the 16S rDNA gene. The sequence showed a strain of O. tsutsugamushi that was quite different from the classic Karp,
Dimitri M. Odorico +7 more
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Laboratory-acquired scrub typhus and murine typhus infections: The argument for risk-based approach to biosafety requirements for Orientia tsutsugamushi and Rickettsia typhi laboratory activities [PDF]
, 2014 This study examined the literature on laboratory-acquired infections (LAIs) associated with scrub typhus (Orientia tsutsugamushi) and murine typhus (Rickettsia typhi) research to provide an evidence base for biosafety and biocontainment.
Blacksell, Stuart D. +3 more
core +4 more sources
Infection of Rodents by Orientia tsutsugamushi, the Agent of Scrub Typhus in Relation to Land Use in Thailand [PDF]
Tropical Medicine and Infectious Disease, 2017 The relationship between land use structures and occurrence of scrub typhus agent, Orientia tsutsugamushi infection in small wild mammals was conducted in three provinces of Thailand: Buriram, Loei, and Nan. Orientia tsutsugamushi detection was performed
Kittipong Chaisiri +2 more
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