Results 241 to 250 of about 1,425,864 (268)

Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer. [PDF]

Discov Oncol
Ding Y, Cai S, Cai J, Wang Z, Zhu Z.
europepmc   +1 more source

Promises and Perspectives of Mesenchymal Stromal Cells in Companion and Farm Animals. [PDF]

Int J Mol Sci
Talluri TR, Nag P, Rathore NS, Kues WA, Kumar D, Selokar N, Bajwa KK, Ansari MM, Bhattacharya TK.   +8 more
europepmc   +1 more source

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Replication licensing — Origin licensing: defining the proliferative state?

Trends in Cell Biology, 2002
The proliferation of eukaryotic cells is a highly regulated process that depends on the precise duplication of chromosomal DNA in each cell cycle. Regulation of the replication licensing system, which promotes the assembly of complexes of proteins termed Mcm2-7 onto replication origins, is responsible for preventing re-replication of DNA in a single ...
J Julian Blow
exaly   +4 more sources

University technology transfer: Contacts and connections at the origin of licensing agreements

Procedia Computer Science, 2022
Technology diffusion and licensing agreements between universities and industry enhance the application of research results and ensures further outcomes for the university stakeholders that take part on the technology transfer process. To this end, University technology transfer offices (TTOs) work with researchers and businesses to bring new ...
Manuela Cruz-Cunha
exaly   +3 more sources

Origin licensing and programmed cell death: a hypothesis

Cell Death & Differentiation, 2002
Initiation of DNA replication in eukaryotic cells is regulated by an `origin licensing' mechanism that requires the sequential assembly of proteins into pre-replicative complexes (pre-RCs) at origins of replication, the sites on chromosomes where DNA synthesis begins (reviewed in reference). Activation of origins in S-phase by cyclin-dependent kinases (
W C, Burhans, Frederic, Blanchard, H, Baumann   +2 more
openaire   +2 more sources

Licensing of Replication Origins

2016
All living organisms need to duplicate their genetic material prior to cell division in order to maintain genomic-stability. Cells have evolved sophisticated DNA replication mechanisms to ensure that this process is as faithful as possible. Eukaryotic initiation of DNA replication is a two-step process, where the replicative DNA helicase becomes loaded
Alberto Riera, Christian Speck
openaire   +1 more source

Regulating the licensing of DNA replication origins in metazoa

Current Opinion in Cell Biology, 2006
Eukaryotic DNA replication is a highly conserved process; the proteins and sequence of events that replicate animal genomes are remarkably similar to those that replicate yeast genomes. Moreover, the assembly of prereplication complexes at DNA replication origins ('DNA licensing') is regulated in all eukaryotes so that no origin fires more than once in
DePamphilis, Melvin L., Blow, J. Julian, Ghosh, Soma, Saha, Tapas, Noguchi, Kohji, Vassilev, Alex   +5 more
openaire   +3 more sources

Licensing the Republication of Foreign Origin Mathematical Tables

Science, 1944
exaly   +3 more sources

H2A.Z facilitates licensing and activation of early replication origins

Nature, 2019
DNA replication is a tightly regulated process that ensures the precise duplication of the genome during the cell cycle1. In eukaryotes, the licensing and activation of replication origins are regulated by both DNA sequence and chromatin features2. However, the chromatin-based regulatory mechanisms remain largely uncharacterized.
Haizhen, Long, Liwei, Zhang, Mengjie, Lv, Zengqi, Wen, Wenhao, Zhang, Xiulan, Chen, Peitao, Zhang, Tongqing, Li, Luyuan, Chang, Caiwei, Jin, Guozhao, Wu, Xi, Wang, Fuquan, Yang, Jianfeng, Pei, Ping, Chen, Raphael, Margueron, Haiteng, Deng, Mingzhao, Zhu, Guohong, Li   +18 more
openaire   +2 more sources

Multiple mechanisms for licensing human replication origins

Nature
Loading of replicative helicases is obligatory for the assembly of DNA replication machineries. The eukaryotic MCM2-7 replicative helicase motor is deposited onto DNA by the origin recognition complex (ORC) and co-loader proteins as a head-to-head double hexamer to license replication origins.
Ran Yang, Olivia Hunker, Marleigh Wise, Franziska Bleichert   +3 more
openaire   +2 more sources