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Essential functions of Cdt1 and Orc6 during origin licensing

Origin licensing ensures that eukaryotic cells replicate their DNA precisely once per cell cycle. The ORC complex, together with the licensing factors Cdc6 and Cdt1, load the core of the replicative helicase (M2-7), as a double hexamer (DH). Licensing starts assembling the helicase loaders ring around duplex DNA (ORC/Cdc6 or OC).
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Originality vs. licensing: Optimal strategies of streaming platforms

Transportation Research Part E: Logistics and Transportation Review
Siyu Du   +3 more
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