Genome-wide mapping reveals single-origin chromosome replication in Leishmania, a eukaryotic microbe [PDF]
Genome Biol, 2015 Background DNA replication initiates on defined genome sites, termed origins. Origin usage appears to follow common rules in the eukaryotic organisms examined to date: all chromosomes are replicated from multiple origins, which display variations in ...
Campbell, Samantha J. +4 more
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Cdc6 ATPase activity regulates ORC center dot Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication [PDF]
, 2007 DNA replication, as with all macromolecular synthesis steps, is controlled in part at the level of initiation. Although the origin recognition complex ( ORC) binds to origins of DNA replication, it does not solely determine their location.
Speck, C., Stillman, B.
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Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system [PDF]
Proc Natl Acad Sci U S A, 2015 R. Stuckey +3 more
semanticscholar +2 more sources
The replication machinery of LUCA: common origin of DNA replication and transcription
BMC Biology, 2020 Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of
E. Koonin +3 more
semanticscholar +1 more source
A study on the correlation of nucleotide skews and the positioning of the origin of replication: different modes of replication in bacterial species [PDF]
, 2005 Deviations from Chargaff's 2nd parity rule, according to which A∼T and G∼C in single stranded DNA, have been associated with replication as well as with transcription in prokaryotes. Based on observations regarding mainly the transcription-replication co-
Almirantis, Yannis +1 more
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The consequences of replicating in the wrong orientation: Bacterial chromosome duplication without an active replication origin [PDF]
, 2015 Chromosome replication is regulated in all organisms at the assembly stage of the replication machinery at specific origins. In Escherichia coli the DnaA initiator protein regulates the assembly of replication forks at oriC.
Dimude, JU +8 more
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Tel1ATM dictates the replication timing of short yeast telomeres [PDF]
, 2014 Telomerase action is temporally linked to DNA replication. Although yeast telomeres are normally late replicating, telomere shortening leads to early firing of subtelomeric DNA replication origins.
Alessandro Bianchi +4 more
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Complexities associated with expression of Epstein-Barr virus (EBV) lytic origins of DNA replication. [PDF]
, 2007 EBV has two lytic origins (oriLyt) of DNA replication lying at divergent sites on the viral genome within a duplicated sequence (DS). The latter contains potential hairpin loops, ‘hinge’ elements and the promoters for transcripts from viral genes BHLF1 ...
Griffin, BE, Xue, SA
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Involvement of G-quadruplex regions in mammalian replication origin activity
Nature Communications, 2019 Genome-wide studies of DNA replication origins revealed that origins preferentially associate with an Origin G-rich Repeated Element (OGRE), potentially forming G-quadruplexes (G4).
Paulina Prorok +13 more
semanticscholar +1 more source
Evolutionary rates and gene dispensability associate with replication timing in the Archaeon Sulfolobus islandicus [PDF]
, 2010 In bacterial chromosomes, the position of a gene relative to the single origin of replication generally reflects its replication timing, how often it is expressed, and consequently, its rate of evolution.
Cooper, Vaughn S. +3 more
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