Results 161 to 170 of about 587,545 (300)

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

A DNA fragment containing the origin of replication of the Escherichia coli chromosome.

Proceedings of the National Academy of Sciences of the United States of America, 1977
R. C. Marsh, A. Worcel
semanticscholar   +1 more source

Statistical inference for factors involved in origin selection and replication timing in baker's yeast

, 2014
Weihong Xu
openalex   +1 more source

Initiation of replication in Xenopus egg extracts at a spatially defined origin [PDF]

, 2015
Kyung Yong Lee, Anindya Dutta
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

SV40 viral minichromosome: preferential exposure of the origin of replication as probed by restriction endonucleases.

Nucleic Acids Research, 1978
A. Varshavsky, O. Sundin, M. Bohn
semanticscholar   +1 more source

Reconciling stochastic origin firing with defined replication timing [PDF]

, 2009
Nick Rhind, Scott Cheng‐Hsin Yang, John Bechhoefer   +2 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Choosing a suitable method for the identification of replication origins in microbial genomes [PDF]

, 2015
Chengcheng Song, Shaocun Zhang, He Huang
openalex   +1 more source

Molecular Dissection of the Essential Features of the Origin of Replication of the Second Vibrio cholerae Chromosome. [PDF]

mBio, 2015
Gerding MA, Chao MC, Chao MC, Davis BM, Waldor MK.   +4 more
europepmc   +1 more source