Results 281 to 290 of about 1,409,521 (314)

The Wing Helix Domain Of Orc4 Is The Primary Determinant Of Dna Binding Specificity Of The Origin Recognition Complex

, 2015
Michael Dowicki
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Autoantibody hotspots reveal the origin and impact of immunogenic XIST ribonucleoprotein complexes in autoimmune diseases. [PDF]

J Clin Invest
Yan B, Lee J, Srinivasan S, Ambriz P, Shi Q, Dou DR, Davuluri S, Nandyala S, Woods A, Leatherman G, Zhao Y, Reggiardo RE, Sawant M, Thiam HR, Shah AA, Fiorentino DF, Chung LS, Chang HY.   +17 more
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Characterisation of Xenopus Origin Recognition Complex

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Structure of the origin recognition complex bound to DNA replication origin

Nature, 2018
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes. Here we report a 3 Å cryo-electron microscopy structure of the Saccharomyces cerevisiae ORC bound to a 72-base-pair origin DNA sequence that contains the ARS consensus sequence (ACS) and the B1 element.
Ningning Li, W. Lam, Y. Zhai, Jiaxuan Cheng, E. Cheng, Yongqian Zhao, N. Gao, B. Tye   +7 more
semanticscholar   +6 more sources

Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome

Nature Genetics, 2011
Meier-Gorlin syndrome is a rare autosomal recessive genetic condition whose primary clinical hallmarks include small stature, small external ears and small or absent patellae. Using marker-assisted mapping in multiple families from a founder population and traditional coding exon sequencing of positional candidate genes, we identified three different ...
D. Guernsey, M. Matsuoka, Haiyan Jiang, S. Evans, C. Macgillivray, M. Nightingale, Scott Perry, Meghan Ferguson, Marissa LeBlanc, J. Paquette, Lysanne Patry, A. Rideout, A. Thomas, A. Orr, C. McMaster, J. Michaud, C. Deal, S. Langlois, D. Superneau, S. Parkash, M. Ludman, D. Skidmore, M. Samuels   +22 more
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Origin Recognition Complex Subunit 1

Definitions, 2020

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Origin recognition complex subunit 1 regulates cell growth and metastasis in glioma by altering activation of ERK and JNK signaling pathway.

Molecular and Cellular Probes, 2019
Origin recognition complex subunit 1(ORC1) is reported to be closely associated with the cell cycle. However, studies on the role of ORC1 in glioma remain undefined.
Wenmin Xiong, C. Xie, Yang Qiu, Z. Tu, Q. Gong   +4 more
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The many faces of the origin recognition complex

Current Opinion in Cell Biology, 2007
The hetero-hexameric origin recognition complex (ORC) is well known for its separable roles in DNA replication and heterochromatin assembly. However, ORC and its individual subunits have been implicated in diverse cellular activities in both the nucleus and the cytoplasm.
Takayo, Sasaki, David M, Gilbert
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ADP-binding to Origin Recognition Complex of Saccharomyces cerevisiae

Journal of Molecular Biology, 2004
The origin recognition complex (ORC), a possible initiator of chromosomal DNA replication in eukaryotes, binds to ATP through its subunits Orc1p and Orc5p. Orc1p possesses ATPase activity. As for DnaA, the Escherichia coli initiator, the ATP-DnaA complex is active but the ADP-DnaA complex is inactive for DNA replication and, therefore, the ATPase ...
Hitomi, Takenaka, Masaki, Makise, Wakako, Kuwae, Naoko, Takahashi, Tomofusa, Tsuchiya, Tohru, Mizushima   +5 more
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Separation of Origin Recognition Complex Functions by Cross-Species Complementation

Science, 1995
Transcriptional silencing at the HMR a locus of Saccharomyces cerevisiae requires the function of the origin recognition complex (ORC), the replication initiator of yeast. Expression of a Drosophila melanogaster Orc2 complementary DNA in the yeast orc2-1
Ehrenhofer-Murray, Ann, Gossen, Manfred, Pak, Daniel T. S., Botchan, Michael R., Rine, Jasper   +4 more
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