Results 211 to 220 of about 4,187 (224)
Some of the next articles are maybe not open access.
Original Antigenic Sin in
ABSTRACTOriginal antigenic sin (OAS) describes the phenomenon in which prior exposure to an antigen weakens the adaptive antibody response to a subsequent heterologous infection. This phenomenon can diminish the effectiveness of immunity acquired through vaccination or previous infections.
Mingran Zhang, Junling Ma, Meili Li
openaire +2 more sources
Original antigenic sin. A confounding issue?
Developments in biologicals, 2004The 'Doctrine of Original Antigenic Sin', first phrased by Francis, Davenport & Hennessy in 1953, and followed up by occasional papers in the 1960s and 1970s, has lived a life in obscurity and negligence ever since it was postulated. From time to time, and with long intervals, papers on the subject appear.
openaire +1 more source
Immunoschismatics: Who is Guilty of Original Antigenic Sin?
1988Original antigenic sin was a term coined by Francis (1) to describe the tendency of a person to produce anti-influenza virus antibody specific for the original immunizing virus upon re-immunization with a related but antigenically distinct virus. In this paper, I will examine this process in terms of the cleavage, by antigen, of an intact immune system
openaire +1 more source
Original Antigenic Sin in Ferrets: the Response to Sequential Infections with Influenza Viruses
The Journal of Immunology, 1966Summary Infection of ferrets with influenza viruses resulted in the production of large numbers of antibody molecules of low avidity. With the passage of time the number of antibody molecules decreased while the average avidity increased.
openaire +2 more sources
Disquisitions of Original Antigenic Sin. I. Evidence in man.
The Journal of experimental medicine, 1967When primary immunity is boosted not by the homologous but by a crossreacting vaccine, the newly formed antibodies react better with the primary antigen than with the antigen actually eliciting the response. This phenomenon bears the name of Original Antigenic Sin (1).
, Fazekas de St Groth, R G, Webster
openaire +1 more source
[Original antigenic sin in the influenza vaccination and its influence].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2019Original antigenic sin may exist in the influenza virus infection or vaccination, which possibly reduces the protective efficacy in repeated influenza vaccination. This paper reviews the literature on the original antigenic sin and its influence in influenza vaccination, and interprets the possible mechanism of this phenomenon from the three aspects of
H D C, Jiang, F C, Zhu
openaire +1 more source
The role of “original antigenic sin” on influenza vaccine response
Vacunas (English Edition), 2022Jordi Reina, Carla Iglesias
openaire +1 more source
Numerical Analysis of the Origin of Immunodominance and Original Antigenic Sin
Journal of the Korean Physical Society, 2008Bum Gyu Shim, Jeong-Man Park
openaire +1 more source