Results 221 to 230 of about 14,580 (242)
Is the emerging influenza A(H3N2) K subclade a specific threat for older adults? [PDF]
GeroscienceQuarleri J, Delpino MV.
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Original Antigenic Sin in Dengue
The American Journal of Tropical Medicine and Hygiene, 1983Sequential blood samples were obtained from eight Thai children before, during and 3-5 months after hospitalization for dengue shock syndrome. All patients experienced a secondary-type antibody response as evidenced by hemagglutination-inhibition antibody responses in acute and convalescent sera. Dengue 2 viruses were recovered from two patients.
S B, Halstead +2 more
openaire +4 more sources
Age profile of immunity to influenza: Effect of original antigenic sin
Theoretical Population Biology, 2012When multiple infections are possible during an individual's lifetime, as with influenza, a host's history of infection and immunity will determine the result of future exposures. In turn, the suite of varying individual infection histories will shape the population level dynamics of the disease.
Kucharski, Adam J., Gog, Julia R.
openaire +4 more sources
Overcoming Original (Antigenic) Sin
Clinical Immunology, 2001Original antigenic sin describes a phenomenon in which the antibody response elicited in an individual after a secondary viral infection reacts more strongly to the viral variant that originally infected the individual. As T helper cells play critical roles in promoting antibody responses, a similar phenomenon may hold true for T helper cell responses.
D E, Anderson +3 more
openaire +2 more sources
Total recall? Understanding the effect of antigenic distance on original antigenic sin
Immunology & Cell Biology, 2023Vaccination-induced antibodies are critical for protective immunity against pathogenic threats. "Original antigenic sin" (OAS), also referred to as imprinting, is the observed phenomenon whereby exposure to antigenic stimuli bias future antibody responses. This Commentary describes a recently elegant model published in Nature by Schiepers et al.
Deborah L Burnett, Rowena A Bull
openaire +2 more sources
Original Antigenic Sin: Experiments with a defined antigen
Molecular Immunology, 1980Abstract The phenomenon referred to as ‘Original Antigenic Sin’ is the production of antibodies to a specific antigen elicited by a boosting injection of a related antigen. We have investigated this phenomenon using myoglobins of known amino acid sequence and structure.
I J, East, P E, Todd, S J, Leach
openaire +2 more sources
Original antigenic sin and the production of autoantibodies
Molecular Immunology, 1985Autoantibodies to sheep myoglobin have been raised by priming sheep with beef myoglobin and boosting with sheep myoglobin. The autoantibodies appear to be a subset of those produced when beef myoglobin is used for both priming and boosting. This subset of antibodies is presumably directed to the surface regions which are common to both myoglobins.
H M, Cooper, P E, Todd, S J, Leach
openaire +2 more sources
Original antigenic sin strikes again?
Science Translational Medicine, 2015Early exposure to an H1 subtype influenza virus may decrease immunity against current H1 viruses in middle-aged adults.
openaire +1 more source
Original antigen sin and COVID-19: implications for seasonal vaccination
Expert Opinion on Biological Therapy, 2022Original antigenic sin describes the phenomenon in which immunity against pathogens or antigens is shaped by the host's first exposure to a related pathogen or antigen.When primary immunity is boosted not by the homologous but by a cross-reacting vaccine, the newly formed antibodies may react better with the primary antigen than with the antigen ...
openaire +2 more sources