Results 231 to 240 of about 14,580 (242)

Original Antigenic Sin in CD4+ T Cells

Immunology
ABSTRACTOriginal antigenic sin (OAS) describes the phenomenon in which prior exposure to an antigen weakens the adaptive antibody response to a subsequent heterologous infection. This phenomenon can diminish the effectiveness of immunity acquired through vaccination or previous infections.
Mingran Zhang, Junling Ma, Meili Li
openaire   +2 more sources

Original antigenic sin. A confounding issue?

Developments in biologicals, 2004
The 'Doctrine of Original Antigenic Sin', first phrased by Francis, Davenport & Hennessy in 1953, and followed up by occasional papers in the 1960s and 1970s, has lived a life in obscurity and negligence ever since it was postulated. From time to time, and with long intervals, papers on the subject appear.
openaire   +1 more source

Immunoschismatics: Who is Guilty of Original Antigenic Sin?

1988
Original antigenic sin was a term coined by Francis (1) to describe the tendency of a person to produce anti-influenza virus antibody specific for the original immunizing virus upon re-immunization with a related but antigenically distinct virus. In this paper, I will examine this process in terms of the cleavage, by antigen, of an intact immune system
openaire   +1 more source

Disquisitions of Original Antigenic Sin. I. Evidence in man.

The Journal of experimental medicine, 1967
When primary immunity is boosted not by the homologous but by a crossreacting vaccine, the newly formed antibodies react better with the primary antigen than with the antigen actually eliciting the response. This phenomenon bears the name of Original Antigenic Sin (1).
, Fazekas de St Groth, R G, Webster
openaire   +1 more source

Original Antigenic Sin

The Science News-Letter, 1960
openaire   +1 more source

Current challenges: from the path of “original antigenic sin” towards the development of universal flu vaccines

International Reviews of Immunology, 2020
Asim Biswas, Shanta Dutta
exaly  

Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes

Nature, 1998
Paul Klenerman
exaly  

Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever

Nature Medicine, 2003
Juthathip Mongkolsapaya, Wanwisa Dejnirattisai, Tao Dong   +2 more
exaly  

Updated, augmented vaccines compete with original antigenic sin

Nature Medicine, 2015
openaire   +1 more source

Numerical Analysis of the Origin of Immunodominance and Original Antigenic Sin

Journal of the Korean Physical Society, 2008
Bum Gyu Shim, Jeong-Man Park
openaire   +1 more source