Results 51 to 60 of about 14,422 (161)
Contemporaneous SARS-CoV-2-Neutralizing Antibodies Mediated by N-glycan Shields
Viruses, 2023 Mutations and the glycosylation of epitopes can convert immunogenic epitopes into non-immunogenic ones via natural selection or evolutionary pressure, thereby decreasing their sensitivity to neutralizing antibodies.
Leili Baghaie +5 more
doaj +1 more source
Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) [PDF]
, 2012 Background: The pir genes comprise the largest multi-gene family in Plasmodium, with members found in P. vivax, P. knowlesi and the rodent malaria species.
Berriman, Matthew +11 more
core +3 more sources
Vaccines, 2018 The first exposure to influenza is thought to impact subsequent immune responses later in life. The consequences of this can be seen during influenza epidemics and pandemics with differences in morbidity and mortality for different birth cohorts.
Ewan P. Plant +5 more
doaj +1 more source
Generation and selection of anti-flagellin monoclonal antibodies useful for serotyping Salmonella enterica [PDF]
, 2013 In developing countries, bacterial acute gastroenteritis continues to be an important cause of morbidity and mortality among young children. Salmonellosis constitutes a major cause of infectious enteritis worldwide, most of them associated to the ...
Algorta, Gabriela +8 more
core +2 more sources
HLA, Immune Response, and Susceptibility to COVID-19
Frontiers in Immunology, 2021 The severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2) that appeared in December 2019 has precipitated the global pandemic Coronavirus Disease 2019 (COVID-19).
Fataneh Tavasolian +9 more
doaj +1 more source
Sequence Space Localization in the Immune System Response to Vaccination and Disease
, 2003 We introduce a model of protein evolution to explain limitations in the immune system response to vaccination and disease. The phenomenon of original antigenic sin, wherein vaccination creates memory sequences that can \emph{increase} susceptibility to ...
Deem, Michael W., Lee, Ha Youn
core +1 more source
Modelling original antigenic sin in dengue viral infection
Mathematical Medicine and Biology: A Journal of the IMA, 2017 Cross-reactive T cell responses induced by a primary dengue virus infection may contribute to increased disease severity following heterologous infections with a different virus serotype in a phenomenon known as the original antigenic sin. In this study, we developed and analyzed in-host models of T cell responses to primary and secondary dengue virus ...
Ryan, Nikin-Beers, Stanca M, Ciupe
openaire +2 more sources
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Cell Reports Medicine, 2021 Summary: Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) with resistance to neutralizing antibodies are threatening to undermine vaccine efficacy.
Daniel J. Sheward +12 more
doaj +1 more source
Original antigenic sin with human bocaviruses 1–4
Journal of General Virology, 2015 Human bocavirus (HBoV) 1 is a widespread parvovirus causing acute respiratory disease in young children. In contrast, HBoV2 occurs in the gastrointestinal tract and is potentially associated with gastroenteritis, whilst HBoV3 and -4 infections are less frequent and have not yet been linked with human disease.
Xuemeng, Li +5 more
openaire +2 more sources
mBio, 2021 Prime-boost vaccinations of humans with different H5 strains have generated broadly protective antibody levels. However, the effect of an individual’s H5 exposure history on antibody responses to subsequent H5 vaccination is poorly understood.
Jiong Wang +7 more
doaj +1 more source