Results 61 to 70 of about 14,422 (161)

Correlations in the T Cell Response to Altered Peptide Ligands

, 2004
The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases.
Arstila, Bachmann, Bachmann, Blattman, Bogarad, Chandler, Deem, Derrida, Derrida, Drossel, Garboczi, Garcia, Jeong-Man Park, Kauffman, Kedl, Kesmir, Klenerman, Lee, Lee, Martin, Michael W. Deem, Perelson, Perelson, Schodin, Singh, Sloan-Lancaster, Sourdive   +26 more
core   +1 more source

Tropomyosin-like properties of clathrin light chains allow a rapid, high-yield purification. [PDF]

, 1983
The light chains (LCa and LCb) of bovine brain clathrin are resistant to heat denaturation by boiling, a property shared by tropomyosin (Bailey, K., 1948, Biochem. J., 43:271-281).
Brodsky, FM, Holmes, NJ, Parham, P
core   +2 more sources

Back to the Future for Influenza Preimmunity—Looking Back at Influenza Virus History to Infer the Outcome of Future Infections

Viruses, 2019
The influenza virus-host interaction is a classic arms race. The recurrent and evolving nature of the influenza virus family allows a single host to be infected several times.
Magen Ellen Francis, Morgan Leslie King, Alyson Ann Kelvin   +2 more
doaj   +1 more source

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources

SARS-CoV-2 Spike Protein Vaccine-Induced Immune Imprinting Reduces Nucleocapsid Protein Antibody Response in SARS-CoV-2 Infection

Journal of Immunology Research, 2022
Immune imprinting or original antigenic sin (OAS) is the process by which the humoral memory response to an antigen can inhibit the response to new epitopes of that antigen originating from a second encounter with the pathogen. Given the situation of the
Juan F. Delgado, Mónica Vidal-Pla, M. Carmen Moya, Mateu Espasa, Antonio Casabella, Manel Seda, Joan Calvet, Jordi Gratacós, Rosa M. Serrano, Pilar Peña   +9 more
doaj   +1 more source

Conservation and global distribution of non-canonical antigens in enterotoxigenic Escherichia coli [PDF]

, 2019
BACKGROUND: Enterotoxigenic Escherichia coli (ETEC) cause significant diarrheal morbidity and mortality in children of resource-limited regions, warranting development of effective vaccine strategies.
Boxrud, Dave, Cebelinski, Elizabeth, Del Canto, Felipe, Fleckenstein, James M, Gómez-Duarte, Oscar G, Hazen, Tracy H, Kuhlmann, F. Matthew Matthew, Martin, John, Mitreva, Makedonka, Okhuysen, Pablo C, Pashos, Madeline, Qadri, Firdausi, Rasko, David A, Vickers, Tim J, Vidal, Roberto   +14 more
core   +2 more sources

Congenital cytomegalovirus infection via a re-infected mother with original antigenic sin: A case report

International Journal of Infectious Diseases, 2018
A 27-year-old pregnant woman who was positive for anti-cytomegalovirus (CMV) antibodies gave birth to a congenitally CMV-infected neonate at 40 weeks of gestation.
Tetsuo Koshizuka, Kuniaki Toriyabe, Yuko Sato, Kazufumi Ikuta, Tomoaki Ikeda, Tatsuo Suzutani   +5 more
doaj   +1 more source

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection [PDF]

, 2016
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC).
A Haque, A Haque, A Haque, A Le Bon, A Pratama, A Pratama, A Sabchareon, AJ McAdam, Andreas Hutloff, Ashraful Haque, BC Rocha, Bryce S. Thomas, C Aucan, C Li, C Shin, C Voisine, CC Kim, CG Matar, Christian R. Engwerda, CL Edwards, D Baumjohann, D Liu, D Perez-Mazliah, D Yu, DJ Wikenheiser, DK Raj, DS Karunarathne, DS Khoury, EA Ball, EG Findlay, ES Coro, Fabian de Labastida Rivera, Fernando Souza-Fonseca-Guimaraes, FH Amante, FH Amante, Fiona H. Amante, G Jego, G Suss, G Trinchieri, Geoffrey R. Hill, H Akiba, H Cucak, H Ueno, H Veiga-Fernandes, H Xu, HC van der Heyde, Ismail Sebina, J Banchereau, J Langhorne, J Li, JA Harker, JA Harker, JC Hall, JL Grun, JP Ray, JP Weber, JW Leavenworth, K Warnatz, Kylie R. James, L Beattie, LB Ivashkiv, Lily G. Fogg, Lynette Beattie, Marcela Montes de Oca, Marcela Montes de Oca, Maria M. Mota, Mark J. Smyth, Megan S. F. Soon, MJ Boyle, MT White, N Obeng-Adjei, NS Butler, O Dienz, Paul J. Hertzog, PF Yong, RA Seder, RA Zander, S Cohen, S Crotty, S Nakayamada, S Pichyangkul, S Portugal, S Sharma, Shannon E. Best, T von der Weid, V Ryg-Cornejo, YS Choi, YS Choi, YS Choi, Z Su   +89 more
core   +5 more sources

Original Antigenic Sin on Antibody Response in SARS-CoV-2 Infection

Infectious Diseases & Immunity
. Infection and vaccination can provide protective immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the emergence of SARS-CoV-2 variants has persisted, leading to breakthrough infections.
Miao Wang, Huimin Guo, Bin Ju, Zheng Zhang, Haijuan Wang   +4 more
doaj   +1 more source

First Impressions Matter: Immune Imprinting and Antibody Cross-Reactivity in Influenza and SARS-CoV-2

Pathogens, 2023
Many rigorous studies have shown that early childhood infections leave a lasting imprint on the immune system. The understanding of this phenomenon has expanded significantly since 1960, when Dr.
Samantha M. King, Shane P. Bryan, Shannon P. Hilchey, Jiong Wang, Martin S. Zand   +4 more
doaj   +1 more source